Nexium is prescribed: with gastroesophageal reflux disease; with acute pancreatitis (to turn off the secretory activity of the gland); with NSAID-associated gastropathy – changes in the walls of the stomach caused by the intake of non-steroidal anti-inflammatory pharmaceuticals; with hypersecretory conditions (stress ulcer, polyendocrine adenomatosis, systemic mastocytosis, Zollinger-Ellison syndrome); with peptic ulcer of the duodenum, stomach (treatment and prevention of relapses); in the scheme of eradication of Helicobacter pylori.
Active ingredient: esomeprazole.
Nexium is produced in the form of lyophilisate for the preparation of a solution (40 mg / vial).
Nexium is an anti-ulcer drug. Acts by inhibiting the work of the proton pump H + / K + -ATPase. When parietal cells enter the canal lumen with an acidic environment, active molecules are oxidized, transforming into an active form. In this form, they bind the SH-groups of the H + / K + -ATPase, irreversibly blocking this enzyme. This leads to a violation of the formation of HCl (hydrochloric acid) – the main component of gastric juice.
Nexium is prescribed:
- with gastroesophageal reflux disease;
- with acute pancreatitis (to turn off the secretory activity of the gland);
- with NSAID-associated gastropathy – changes in the walls of the stomach caused by the intake of non-steroidal anti-inflammatory pharmaceuticals;
- with hypersecretory conditions (stress ulcer, polyendocrine adenomatosis, systemic mastocytosis, Zollinger-Ellison syndrome);
- with peptic ulcer of the duodenum, stomach (treatment and prevention of relapses);
- in the scheme of eradication of Helicobacter pylori.
- with intolerance to the components of the drug;
- while taking nelfinavir, atazanavir.
Application during pregnancy and lactation
During pregnancy, Nexium is used with caution. This medicine is not used during breastfeeding.
Method of administration and dosage
Nexium lyophilisate is used parenterally (intravenously).
For patients who are contraindicated in oral forms of the drug, the drug is prescribed at a dose of 40 mg once a day. Increase the dose if necessary.
The solution should be used immediately after preparation.
Possible overdose symptoms: dyspepsia, weakness.
Overdose relief measures include stopping treatment, maintenance therapy.
- Blood changes: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.
- Neurological disorders: blurred vision, headache, insomnia, paresthesia, dizziness, drowsiness, agitation, depression, aggression, confusion, hallucinations.
- Digestive disorders: flatulence, nausea / vomiting, abdominal pain, constipation / diarrhea, dry mouth, taste disturbance, gastrointestinal candidiasis, stomatitis, microscopic colitis, increased liver transaminase activity, hepatitis with / without jaundice, liver failure, hepatic encephalopathy.
- Respiratory disorders: bronchospasm.
- Dermatological disorders: dermatitis, urticaria, pruritus, rash, alopecia, photosensitivity, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, subacute cutaneous lupus erythematosus.
- Musculoskeletal disorders: hip fractures, fracture of the wrist bones, fracture of the vertebrae, myalgia, arthralgia, muscle weakness.
- Genitourinary disorders: interstitial nephritis, renal failure, gynecomastia.
- Immune disorders: fever, anaphylactic reaction / shock, angioedema.
- Metabolic disorders: peripheral edema, hyponatremia, severe hypomagnesemia.
- General disorders: malaise, sweating.
Storage conditions and periods
At 15-30 ° C. Shelf life of lyophilisate is 2 years.