Nifedipin (nifedipine) coated tablets 0.01 g. №50


Nifedipine is used when: ischemic heart disease – angina of tension and rest; arterial hypertension.



Nifedipin composition and form of release
The main active ingredient is nifedipine.
The drug is marketed in the form of tablets, 10 mg of nefidipine in 1 tablet.

Pharmacological properties
Nifedipin belongs to the group of selective calcium antagonists with a predominant effect on blood vessels.
The active ingredient is nifedipine. The considered pharmaceutical component, when used appropriately, has the property of lowering arterial pressure. Blocks calcium channels, inhibiting calcium ions, as a result of which the accumulation of calcium ions in cells decreases. As a result, the coronary and peripheral vessels dilate, which leads to a decrease in systemic vascular resistance, and as a result – cardiac load, afterload and activation of oxygen supply to the heart muscle.
In general, the use of the drug prevents the depletion of energy reserves in the heart muscle, protecting it, and also lowers blood pressure, preventing angina attacks, as well as migraine attacks. In addition, therapy with nifedipine induces a normalization of the heart rate.

Nifedipin is used in the treatment of such diseases of the cardiovascular system, in particular:

  • ischemic heart disease, exertional angina and rest;
  • arterial hypertension.

The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.
Also contraindicated for:

  • myocardial infarction in the acute phase, cardiogenic shock;
  • heart failure, severe stage of arterial hypotension;
  • tachycardia, a severe form of aortic stenosis.

Caution should be exercised when treating patients with this drug suffering from:

  • chronic heart failure;
  • significant violations of the liver or kidneys;
  • severe forms of cerebrovascular accident;
  • diabetes mellitus, porphyria;
  • Crohn’s disease.

Application during pregnancy and lactation
The drug should not be administered during pregnancy.
If there is a need to use this drug during lactation, then breastfeeding should be suspended for this period.

Method of administration and dosage
Nifedipin is taken orally, regardless of food intake, with water.
The recommended dosage is 20 mg of nifedipine 2 times a day (morning and evening).
The maximum dose per day is no more than 60 mg.
Correction of dosage and duration of treatment is determined individually by the attending physician.

Overdose can cause:

  • drop in blood pressure;
  • bradycardia, heart failure, shock;
  • metabolic acidosis, seizures.

In this case, you need to flush the stomach, carry out symptomatic treatment.

Side effects
When treating with this drug, side effects may occur such as:

  • nausea, constipation, diarrhea, flatulence, black stools, intestinal ulcers, gingival hyperplasia, dry mouth;
  • itching, allergic urticaria, exanthema, autoimmune hepatitis;
  • tachycardia, arterial hypotension, edema, hyperemia, myocardial infarction;
  • headache, migraine, insomnia, drowsiness, depression;
  • myalgia, arthralgia, convulsions, joint swelling;
  • polyuria, nocturia, hematuria, dysuria;
  • anemia, leukopenia, thrombocytopenia, agranulocytosis;
  • decreased visual acuity and hearing;
  • erectile dysfunction, chills.

Storage conditions and periods
Expiration date – no more than 2 years from the date of issue indicated on the packaging by the manufacturer.
Storage temperature should not exceed 25 ° C.