Nifuroxazid (nifuroxazide) coated tablets 200 mg. №20


Acute diarrhea of infectious etiology.



Nifuroxazid composition
Active ingredient: nifuroxazide.
excipients: colloidal anhydrous silica, potato starch, gelatin, talc, magnesium stearate; shell: hypromellose (E 464), polyethylene glycol, quinoline yellow (E 104), titanium dioxide (E 171), talc.

Release form
Available in tablets form (200 mg).

Pharmacological properties
This is an antimicrobial medicine. The active ingredient inhibits the activity of the enzyme dehydrogenase in bacteria, disrupting protein production. The drug is effective against most pathogens of intestinal infections. Has a local antibacterial effect (activated in the intestinal lumen). It is effective against some types of pathogenic bacteria of the Staphylococcus family (staphylococci), the Enterobacteriaceae family of Escherichia sp., Citobacter sp., Yersinia sp., Klebsiella sp., Salmonella sp., Enterobacter sp. In medium doses, it exhibits a bacteriostatic effect (stops the growth of bacteria), and in higher doses, it is bactericidal (kills bacteria).

Nifuroxazid is used for acute diarrhea (loose and frequent stools) of infectious origin.

Nifuroxazid should not be used:

  • if you are allergic to nitrofuran derivatives;
  • with intolerance to excipients.

It is used in pediatrics for children from six years of age.

Application during pregnancy and lactation
There are no sufficient reliable data on fetotoxic (causing fetal poisoning), teratogenic (causing the development of deformities) effects. Therefore, the appointment of this medication for pregnant women is not recommended.
It is allowed to prescribe the drug to women during breastfeeding (subject to short-term therapy).

Method of administration and dosage
Nifuroxazid should be taken orally with water. Reception is not tied to food intake.
Adult patients, children over 15 years of age are prescribed 200 mg up to 4 times a day. Children from six years old are prescribed 200 mg 3-4 times a day.
The maximum daily dose is 800 mg.
The duration of the treatment course should not exceed 7 days. If during this time the symptoms do not disappear, it is necessary to reconsider the diagnosis and treatment regimen.
Treatment must be combined with the appointment of a dietary regimen, rehydration measures (restoration of the volume of body fluids). If diarrhea (loose stools) does not stop within three days from the start of treatment, you should consult a doctor.

Symptoms: diarrhea, drowsiness.
In case of overdose, gastric lavage is recommended (within an hour after poisoning), supportive and symptomatic treatment.

Side effects:

  • Immune disorders: allergic reactions, including Quincke’s edema (swelling of the lips, face, tongue), pruritus, urticaria, anaphylactic shock, obstruction of the respiratory tract, itching, skin rashes.
  • Digestive disorders: exacerbation of diarrhea, temporary abdominal pain, nausea.
  • Skin changes: itching, rashes, palmar-plantar pustules, urticaria.

In case of development of adverse reactions, it is necessary to stop taking the medication and further avoid the use of nitrofuran derivatives.

Storage conditions and periods
Store Nifuroxazid in a dry, dark place at room temperature (15-25 ° C). The expiration date of the medicine is indicated on the package. Parents must ensure the safety of their children by limiting their access to medicines.