Nitrogranulong tablets with prolonged release 5,2 mg №50


Nitrogranulong is used for the prevention of angina attacks, including coronary heart disease and in the postinfarction period.



Nitrogranulong composition
Main active ingredient: nitroglycerin.
Excipients: lactose monohydrate, potato starch, talc, magnesium stearate, povidone, white sugar, corn starch, anhydrous colloidal silicon dioxide, titanium dioxide, gelatin, polyethylene glycol or macrogol.

Release form
It is produced in the form of prolonged-release tablets, each of which contains 5,2 mg of nitroglycerin.

Pharmacological properties
Nitrogranulong belongs to the group of pharmaceuticals-vasodilators, organic nitrates, which are used in the treatment of cardiac diseases.
Refers to antianginal, vasodilator, coronary dilator drugs.
The drug effectively relieves angina attacks due to the mechanism of action of nitric oxide (free radical) released when entering the body. Poledniy has the property of activating guanylate cyclase, causing an increase in the content of a certain monophosphate in the smooth muscle cells of blood vessels, which, in turn, causes relaxation of the smooth muscle fibers of the blood vessel walls.
In addition, nitroglycerin has a sympathomimetic effect on the heart muscle, releases catecholamines in the brain, myocardium, and affects the troponin-tropomyosin complex.
It inhibits vascular tone due to its ability to inhibit the emerging pain syndrome.
With heart failure and angina pectoris, it causes an increase in cardiac output, allows you to successfully endure physical activity, and reduces both the severity and the number of heart attacks.
Reduces the load of venous blood on the heart, lowering the filling of the left ventricle (diastolic), lowering the total peripheral vascular resistance, blood pressure.
As a result of these properties, the load on the heart and the oxygen demand of the heart muscle are reduced, improving coronary blood flow, increasing the threshold for the possible occurrence of ischemia of the heart muscle.

Nitrogranulong is used for the prevention of angina attacks, including coronary heart disease and in the postinfarction period.

You should not use the specified drug if the patient has had a previous hypersensitivity (allergy) with respect to one of the components that are part of the drug – both basic and auxiliary.
Also, use is contraindicated for:

  • shock, collapse, arterial hypotension;
  • acute myocardial infarction with low left ventricular filling pressure;
  • hypertrophic obstructive cardiomyopathy;
  • increased intracranial pressure (including with hemorrhagic stroke, after a recent head injury);
  • angle-closure glaucoma;
  • bradycardia, cerebral ischemia, cardiac tamponade.

Do not use concomitantly with sildenafil and other phosphodiesterase inhibitors.
Use with caution in hypovolemia, anemia, hyperthyroidism, impaired cerebral circulation, severe renal or hepatic failure, aortic stenosis, toxic pulmonary edema.
Do not drink alcohol!
Do not use the sauna, do not take hot showers / bathrooms.

Application during pregnancy and lactation
Treatment of pregnant women with this drug is contraindicated.
During treatment with this drug, breastfeeding should be suspended.

Method of administration and dosage
To avoid becoming addicted to Nitrogranulong, it should not be taken more often than once every 10-12 hours. Nitrogranulong is swallowed with a little water.
Recommended dosages:

  • for mild pain – 1-2 tablets at a dosage of 2.9 mg of the drug;
  • for severe pain – 1-2 tablets at a dosage of 5.2 mg of the drug.

The maximum daily dosage is no more than 30 mg of nitroglycerin.

An overdose of this drug can cause the body to react in the form of:

  • lowering blood pressure below 90 mm Hg;
  • headache, dizziness;
  • fainting, tachycardia;
  • nausea, vomiting;
  • shortness of breath, weakness;
  • fever, fever, increased sweating, chills.

When using a dosage higher than 20 μg per 1 kg of body weight, the patient may experience collapse, cyanosis of the lips, nails or palms, methemoglobinemia, dyspnea and tachypnea.
With symptoms of an overdose of nitroglycerin, the patient needs to be helped to take a horizontal position by lifting the lower limbs.
In case of excessive overdoses, symptomatic treatment is prescribed, plasma substitutes, oxygen are given, with methemoglobinemia – methylene blue.

Side effects
Side effects can occur in the form:

  • reflex tachycardia, hyperemia of the skin;
  • sensations of heat, arterial hypotension, including orthostatic collapse, cyanosis, pallor of the skin, methemoglobinemia;
  • nausea, vomiting, dry mouth, abdominal pain, diarrhea;
  • excitability, visual impairment, exacerbation of glaucoma, hypothermia.
  • allergic reactions including skin rash, itching, anaphylactic shock.

In rare cases, a reverse reaction of the body is possible in the form of an increase in the symptoms of angina pectoris (the so-called paradoxical “nitrate” reactions).

Storage conditions and periods
This medicinal product is able to retain its medicinal properties for 3 years from the date of manufacture.
Storage temperature should not exceed 25 ° С