Noliprel Bi-forte coated tablets 10/2,5 mg. №30


Noliprel Bi-forte is indicated for the treatment of essential or primary hypertension (prolonged and persistent high blood pressure).



Noliprel Bi-forte composition
Combined preparation containing active ingredients: tert-butylamine salt of perindopril (10 mg), indapamide (2.5 mg), excipients.

Release form
Produced in tablet form.

Pharmacological properties                                                                                                                                              It has the property of reducing both systolic and diastolic blood pressure in patients regardless of age, both in a horizontal and vertical position. The effect of the drug is dose-dependent.
Among others, perindopril has the property of decreasing the work of the heart muscle, due to the vasodilating effect on the veins, reducing the afterload on the heart, generally leading to a decrease in blood pressure associated with a decrease in the filling of the left and right ventricles of the heart, an improvement in its index, and an increase in regional muscle blood flow. It also has the ability to expand the lumen in blood vessels, restoring their elasticity, and reducing left ventricular hypertrophy.
Indapamide, in turn, is able to increase the secretion of sodium, chlorine, potassium and magnesium, which helps to increase urinary excretion, which also helps to lower blood pressure.
Thanks to the listed characteristics, Noliprel Bi-Forte normalizes blood pressure for only one month, while it does not have a tachyphylaxis effect.

Noliprel Bi-forte is indicated for the treatment of essential or primary hypertension (prolonged and persistent high blood pressure).

You should not prescribe this drug if you are allergic to perindopril, ACE inhibitors, sulfonamides. Also, you should not take it in severe forms of kidney failure, liver failure, if the patient has hypokalemia, or is undergoing hemodialysis.

It is not used in pediatrics.

Application during pregnancy and lactation
Not assigned.

Method of administration and dosage
For oral use. Take Noliprel Bi-forte 1 time per day, 1 tablet, in the morning before breakfast.

In case of an overdose of this drug, hypokalemia, hyponatremia may develop, accompanied by symptoms – nausea, vomiting, seizures, polyuria, oliguria, anuria, a sharp drop in blood pressure.
In this case, the drug is temporarily canceled, symptomatic treatment is prescribed.

Side effects
Side effects may occur in the form of excessive pressure drop, thrombocytopenia, agranulocytosis, leukopenia, neutropenia, aplastic anemia. Skin allergic reactions (itching, urticaria, erythema), dyspeptic symptoms (nausea, vomiting), impotence, pancreatitis, angina pectoris, hepatitis, rhinitis, increased sweating are possible. Renal failure, allergic bronchospasm, and myocardial infarction may also occur.

Storage conditions and periods
Stored for up to 3 years at room temperature in a tightly closed container.