Normopres (captopril, hydrochlorothiazide) tablets №20


Normopres is prescribed for various forms of arterial hypertension.



Normopres composition and form of release
Active ingredients: captopril, hydrochlorothiazide.
Available in tablet form (50 mg + 25 mg).

Pharmacological properties
Normopres is a combination medicine (ACE inhibitor + diuretic) for the treatment of hypertension. The drug, inhibiting the formation of angiotensin II, eliminates its vasoconstrictor effect and a stimulating effect on the production of aldosterone in the adrenal glands. At the same time, the total resistance of peripheral vessels decreases and, accordingly, blood pressure. The preload on the heart muscle also decreases, the pressure in the right atrium decreases, as well as the pulmonary circulation. The diuretic substance (hydrochlorothiazide) increases the excretion of Cl, Na, K ions from the body, and water.

Normopres is prescribed for various forms of arterial hypertension.

You can not use Normopress:

  • with allergies to the components of the drug;
  • if you are allergic to other ACE inhibitors;
  • with chronic kidney disease at IV-V stage;
  • with stenosis of the artery of a single kidney;
  • with a condition after a kidney transplant;
  • with bilateral renal artery stenosis;
  • with subaortic / aortic / mitral stenosis;
  • with severe liver dysfunction (hepatic coma, pre-coma);
  • with primary hyperaldosteronism;
  • with hypokalemia, hyponatremia, especially in combination with hypovolemia (dehydration);
  • with hypercalcemia;
  • with gout.

It is prescribed with caution in patients with severe cardiac dysfunction, with chronic kidney disease at stages I – III, with renal hypertension, with diabetes mellitus, elderly (from 65 years), with vascular lesions in collagenoses.

It is not used in pediatrics.

Application during pregnancy and lactation
Not applicable.

Method of administration and dosage
Normopres is taken orally (by mouth) one hour before meals. Doses are selected in accordance with the clinical picture of the disease.
The starting dose is half a tablet (25 mg captopril + 12.5 mg hydrochlorothiazide) x1 times / day. In the future, the dose can be increased (if necessary) up to 1 tablet x2 times / day (100 mg + 50 mg).
The duration of treatment is determined individually.

Typical symptoms: a sharp drop in blood pressure, lack of appetite, tachycardia, headache, taste disturbance, neutropenia, allergic reactions, shock, stupor, electrolyte imbalance, bradycardia, renal failure, weakness, vomiting, diarrhea, coma, shock, thirst, alkalosis , polyuria / oliguria / anuria, increased blood urea nitrogen, confusion, muscle spasm, paresthesia.

In case of severe symptoms of an overdose, hospitalization is required for detoxification measures, dialysis, as well as normalization of the function of the respiratory, cardiovascular, and central nervous systems.

Side effects
Possible cardiac arrhythmias, drop in blood pressure, palpitations, cerebrovascular accidents (ischemic), tachycardia, myocardial infarction, cardiac arrest, pallor, cardiogenic shock, bronchitis, sinusitis, rhinitis, bronchospasm, laryngitis, dry cough, pneumonitis, pulmonary edema, dyspnea, alveolitis, angina pectoris, Raynaud’s syndrome, pneumonia, chest pain, proteinuria, glucosuria, polyuria / oliguria / polyuria, acute renal failure, interstitial nephritis, nephrotic syndrome, hypomagnesemia, hypercalcemia, hyponatremia, hyperuricemia, hypercholesterolemia, increased triglycemia , violation of taste sensations, discomfort over the stomach, dry mouth, nausea, aphthous stomatitis, increased ALT / AST, hyperbilirubinemia, vomiting, constipation / diarrhea, cholestatic jaundice, pancreatitis, hepatitis, glossitis, peptic ulcer, drowsiness, sleep disturbances, headache , convulsions, ataxia, dizziness, paresthesia, taste disturbance, anxiety, fainting, depression , confusion, gynecomastia, impotence, anemia, leukopenia, eosinophilia, thrombocytopenia, neutropenia, agranulocytosis, pancytopenia, necrotizing angiitis, skin rash, angioedema, urticaria, pruritus, erythema multiforme, exfoliative dermatopodia, body temperature arthralgia, photosensitivity, blurred vision, weakness, xanthopsia, sialadenitis, lymphadenopathy.

Storage conditions and periods
No more than 2 years at 15-25 ° С.