Olfen-100 SR Depocaps (diclofenac sodium) 100 mg. №20


Adults are prescribed for pain syndrome of different localization, as well as: postoperative pain, swelling, and inflammation; inflammatory and degenerative forms of rheumatic diseases (juvenile rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, spondyloarthritis, ankylosing spondylitis); acute gout; extra-articular rheumatism; post-traumatic inflammatory processes; gynecological diseases (dysmenorrhea, adnexitis); migraine of various degrees; inflammatory diseases of the ENT organs (otitis, pharyngitis, tonsillitis, toothache); fever; renal and hepatic colic.



Olfen-100 SR Depocaps composition
The main active ingredient of the drug is sodium diclofenac. Excipients are lactose monohydrate, microcrystalline cellulose, glycerol trimistat, triethyl citrate, colloidal anhydrous silicon dioxide, erythrosine, etc.

Release form
It is produced in the form of capsules of prolonged action, in a dosage of 100 mg of diclofenac in 1 capsule.

Pharmacological properties
Olfen-100 SR Depocaps is a non-steroidal drug based on sodium diclofenac. The main active ingredient of this drug has a pronounced analgesic, anti-inflammatory and antipyretic effect.
The mechanism of action is due to the ability to inhibit the biosynthesis of prostaglandins. The latter play an important role in the genesis of inflammation, pain and fever.
In the recommended doses, diclofenac does not inhibit the biosynthesis of proteoglycans in cartilage tissue.

Olfen-100 SR Depocaps is prescribed to treat symptoms of pain and inflammation, if the patient is diagnosed with:

  • rheumatoid arthritis;
  • ankylosing spondylitis;
  • osteoarthritis;
  • spondyloarthritis;
  • pain syndrome of various localization;
  • extra-articular rheumatism;
  • swelling with pain syndrome;
  • post-traumatic inflammatory processes (including due to fractures, dislocations, and other orthopedic injuries).

Diclofenac sodium has the property of reducing blood coagulation and potentiates, that is, enhances the effect of anticoagulants.
The use of this drug for the above diseases reduces pathological changes in tissues in the zone of inflammation, while pain sensations decrease, morning stiffness of the joints and their swelling disappear, and the functional state of the musculoskeletal system increases.
Taking diclofenac sodium reduces the need for opioids in patients experiencing severe pain, in particular postoperative pain.
A stable effect develops after 1-2 weeks after starting the drug intake.

It is contraindicated to take this drug if the patient is allergic to diclofenac, or other ingredients that make up it, as well as in cases where acetylsalicylic acid or other nonsteroidal drugs cause attacks of asthma, urticaria or acute rhinitis.
Do not accept if available:

  • a stomach or intestinal ulcer;
  • gastrointestinal bleeding or perforation;
  • proctitis;
  • hemorrhoids;
  • rectal bleeding;
  • other active bleeding;
    dysfunction of the heart, liver, kidneys;
  • disorders of hematopoiesis of unknown origin;
  • peripheral arterial disease.

It is not used in pediatrics.

Application during pregnancy and lactation
Use with great caution during pregnancy. In the third trimester, this drug is contraindicated.
You should stop breastfeeding while taking this drug.

Method of administration and dosage
Taking Olfen-100 SR Depocaps is prescribed with the lowest possible dosage and for the minimum necessary time.
Take 1 capsule 1 time per day, before meals, without chewing and drinking a glass of water.
If you need to relieve night pain or morning stiffness of movements, you need to take the drug before bedtime.
The maximum daily dose is 150 mg.
Elderly patients and those suffering from mild or moderate liver and / or kidney dysfunction do not need dosage adjustment.

In case of an overdose of diclofenac sodium, the body does not react with any specific symptoms. The most common signs of poisoning are:

  • vomiting;
  • gastrointestinal bleeding;
  • diarrhea (diarrhea);
  • tinnitus;
  • convulsions;
  • drop in blood pressure.

Acute renal failure, liver dysfunction can be observed with a severe degree of poisoning.
Treatment is symptomatic. Hemodialysis or forced diuresis is ineffective.

Side effects
Taking this drug can cause side effects in the form of:

  • pain in the epigastrium;
  • nausea, vomiting, diarrhea, abdominal cramps;
  • dyspepsia, gastrointestinal bleeding;
  • ulcers of the stomach and intestines;
  • glossitis, stomatitis, lesions of the esophageal mucosa;
  • intestinal adhesions;
  • constipation, pancreatitis;
  • headaches, drowsiness, anxiety, nightmares, hair loss;
  • skin rashes, urticaria, eczema, erythema multiforme;
  • edema, renal failure, hematuria, nephrotic syndrome, papillary necrosis;
  • hepatitis, agranulocytosis, thrombocytopenia, leukopenia, anemia;
  • tachycardia, chest pain, lowering blood pressure.

Storage conditions and periods
Stored for up to 5 years at a temperature not exceeding 25 ° C.