Predizin coated tablets with prolonged release 35 mg. №60

$26.00

Predizin is prescribed for the symptomatic treatment of stable angina pectoris (in case of insufficient effectiveness or intolerance to antianginal drugs of the 1st line).

Category: Manufacturer: Poland

Description

Predizin Composition and form of release
Active ingredient: trimetazidine dihydrochloride (35 mg).
Available in the form of extended-release tablets.

Pharmacological properties
Cytoprotective agent. The drug protects the structure of cells, the function of various tissues and organs from hypoxia (oxygen starvation), ischemia, as well as metabolic disorders provoked by them. This effect is especially evident in the heart and neurosensory organs, without directly affecting hemodynamics. Increases the threshold of ischemic damage to the heart muscle, which is manifested by a delay in the onset of depression of the ST segment, a decrease in the degree of this depression. It also improves the ability to perform physical activity, the adaptive ability of the myocardium, coronary reserve. It does not reduce the heart rate and / or blood pressure.

Indications
Predizin is prescribed for the symptomatic treatment of stable angina pectoris (in case of insufficient effectiveness or intolerance to antianginal drugs of the 1st line).

Contraindications
You cannot assign Predizin:

  • with intolerance to the components of the drug;
  • during pregnancy;
  • when breastfeeding;
  • children under 18;
  • with Parkinson’s disease, tremor, parkinsonism, restless legs syndrome, other movement disorders related to these conditions;
  • with severe renal failure (creatinine clearance rate less than 30 ml / minute).

Application during pregnancy and lactation
During breastfeeding, pregnancy is not used.

Method of administration and dosage
Predizin is taken orally (by mouth) with food.
Adults are shown 35 mg 2 times a day.
The course of therapy is determined by the severity, nature of the course of the disease.
Patients with moderate kidney failure (creatinine clearance rate – 30-60 ml / minute) is recommended a dose of 35 mg per day (in the morning with breakfast).
In elderly people, the concentration of the drug in the blood may be higher due to age-related decline in renal function, so it is necessary to carefully titrate the dose.

Children
The safety and effectiveness of this drug for children (under 18 years of age) have not been established.

Overdose
Overdose cases with this medicine have not been registered.
Overdose treatment: dose reduction or drug withdrawal, symptomatic therapy.

Side effects:

  • Neurological disorders: sleep disorders (insomnia or drowsiness), the onset of symptoms of parkinsonism (muscle hypertonicity, akinesia, tremor), headache, dizziness, restless legs syndrome, gait instability, other movement disorders (are reversible). Cardiac disorders: palpitation, extrasystole, tachycardia.
  • Vascular disorders: facial redness, orthostatic hypotension (manifested by malaise, dizziness, or falling when changing body position), arterial hypotension.
  • Digestive disorders: abdominal pain, diarrhea, nausea, constipation, vomiting.
  • Hepatobiliary Disorders: Hepatitis.
  • Dermatological disorders: rash, generalized exanthematous pustular rash, pruritus, urticaria, angioedema.
  • Hematological disorders: agranulocytosis, thrombocytopenic purpura, thrombocytopenia.
  • General disorders: asthenization.

Storage conditions and periods
It is required to store the drug in undamaged packaging at temperatures up to +25 degrees Celsius. The shelf life of Predizin is three years. Parents must keep their children safe by limiting their access to medicines.