Prednitop (prednicarbat) cream 0.25% 10 g. tube


Inflammatory diseases of the skin that require treatment with corticosteroids for local use. Prednitop, an cream, is used for the treatment of acute and chronic diseases of the skin when the skin is wet, normal or dry.


Prednitop Composition
Benzyl alcohol, cetyl alcohol, 2.5 mg prednicarbate, purified water, light mineral oil, sorbitan stearate, myristyl alcohol, polysorbate 60.

Release form
Prednitop is produced in the form of an opaque, slightly shiny white cream, sealed in a tube, 10 g each, which is packed in a cardboard box, 1 tube each.

Pharmacological properties
Prednicarbate, which is part of the drug Prednitop, specially designed for external use, a potent glucocorticoid with a pronounced anti-inflammatory, anti-allergic, anti-exudative, antiproliferative and antipruritic effect.
The antiproliferative effect of glucocorticoids is due to the reduced circulation rate of the involved cells and the reduced intensity of DNA synthesis. This is known to result in inhibition of granulation, wound closure, and fibroblast proliferation.
The antiallergic action of glucocorticoids is explained by their immunosuppressive action and effect on antibody- and cell-mediated hypersensitivity. The immunosuppressive action of glucocorticoids is based mainly on the reduction of the number and activity of lymphocytes (T-lymphocytes), B-cells.
Antibody-mediated hypersensitivity is also affected by inhibition of the release of vasoactive substances (eg, histamine), and cell-mediated hypersensitivity is affected by a decrease in the release of lymphokines.
The anti-inflammatory effect is based in part on the effect on the metabolism of arachidonic acid and, as a consequence, on the reduction of the formation of inflammatory mediators (eg, prostaglandins, leukotrienes). On the other hand, excessive cell signals are reduced to normal.
The results of double-blind studies showed that from the point of view of clinical efficacy of precarbate, despite the fact that it does not contain halogen, it is equivalent to halogenated corticoids such as betamethasone valerate, deoxymethasone or fluorocortholone.
The extremely small effect of prednicarbate on collagen synthesis and the growth of fibroblasts in human skin reflects the insignificant atrophogenic ability of the active substance. Inhibition of the synthesis of autogenous cortisol after application to a large area of ​​the affected skin (psoriasis, neurodermatitis) in the case of prednicarbate was not observed.

Indications for use
Inflammatory diseases of the skin areas, redness of the skin, vesicles that have formed on the skin areas, allergic diseases are indications for the use of this medication.

Hypersensitivity to the ingredients that make up this drug; perioral dermatitis, infectious skin diseases, rosacea, chickenpox, tuberculosis, herpes, syphilis, rosacea – contraindications, in the presence of which the drug should not be used!

Pregnancy and breastfeeding period
If, when using this medication, there are no risks to deteriorate your health and your baby, then the use is recommended, but if the risks are high, then it is not advised to take this drug so as not to harm you and your future baby. Also, before use, nursing mothers or pregnant women are advised to go to the doctor for recommendations.

Mode of application
Taking each medication, all sick patients want to avoid identifying side effects or avoiding an overdose, so everyone is advised not to self-medicate at home, but to go to a specialist in your diseases and consult about the dosage of this medication.
The standard dose for the use of the medicine: approximately 1-2 times a day, apply a thin layer of ointment to the affected skin area, while gently rubbing and completely covering the patient’s affected skin area.
The drug is recommended by doctors to use within 2 weeks. To continue treatment – see your doctor for appointments.

Vomiting, nausea, dizziness, headache, rashes on the skin, as well as an increase in all side reactions of the body to the components that make up the drug are symptoms that are recorded in patients using the dosage of the drug to a greater extent than the treating person attributed to them doctor.

Adverse reactions
Patients who took this drug have reported the following side effects: skin irritation, skin redness, pruritus, stretch marks, secondary infection, burning sensation, prickly heat, perioral dermatitis, skin atrophy, acne, skin maceration. When fixing these reactions, you are recommended to go to your doctor who will prescribe you additional treatment for these symptoms.

Storage conditions
A place inaccessible to children, the temperature does not exceed 25 ° C, dark, dry, without the sun’s rays getting there – all these are conditions for storing this medication, which every sick patient must observe in order to avoid negative consequences in the future.
The shelf life of Prednitop lasts for 36 months from the date of manufacture, which you can find out on the packaging of each medicine.