Prednizolon (prednisolone) ointment 0.5% 10 g. tube


As part of the complex therapy of inflammatory and allergic skin diseases of non -microbial etiology: eczema, seborrheic dermatitis, psoriasis, lupus erythroderma.


Prednizolon Composition
Active ingredient: 1 g of ointment contains: prednisolone (in terms of 100% substance) – 5 mg;
Excipients: glycerin, soft yellow paraffin, purified water, stearic acid, emulsifier No. 1, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216).

Dosage form

Pharmacological properties
Glucocorticosteroids (GCS) for local (external) use have anti-inflammatory, epidermal, antiallergic, immunosuppressive and local anesthetic effects. The anti-inflammatory effect is accompanied by vasoconstriction, a decrease in itching and pain at the site of application, a violation of the migration of lymphocytes and macrophages in the focus of inflammation. GCS have an antimitotic and antiproliferative effect. An important aspect of the anti-inflammatory action of GCS is the stimulation of the formation of lipocortin, which reduces the formation of arachidonic acid and thereby reduces the formation of mediators of inflammation and allergy. Stabilization of cell membranes plays an essential role in the mechanism of action of GCS. When applied to the skin, it practically does not have systemic glucocorticoid and mineralocorticoid effects.

Indications for use
As part of the complex therapy of inflammatory and allergic skin diseases of non-microbial etiology: eczema, seborrheic dermatitis, lupus erythematosus, erythroderma.

Wound or ulcerative lesions, bacterial, viral and fungal skin diseases, Cushing’s syndrome, chickenpox, herpes simplex, vaccination period, cutaneous manifestations of syphilis, skin tuberculosis, skin tumors, common acne, rosacea (possible exacerbation of the disease), hypersensitivity to drug components , shingles, perioral dermatitis, atrophic dermatitis, skin reactions after vaccination in the area of ​​application of the drug.

Application during pregnancy or lactation                                                                                                                   The drug Prednizolon should not be administered to pregnant women. Breastfeeding women are advised to stop either breastfeeding or the use of the drug, especially at high doses.

Method of administration and dosage
Apply Prednizolon externally, apply the ointment 1-3 times a day in a uniform thin layer on the affected area, rubbing lightly into the skin. In limited areas of inflammation, it is possible to use occlusive dressings to enhance the effect.
The duration of the course of treatment is 6-14 days. Do not use the drug for more than 14 days. When prescribing to children aged 1 year and older, the total duration of treatment should be limited to 5-7 days and activities leading to an increase in the resorption and absorption of the steroid (warming, fixing and occlusive dressings) should be excluded.

For children, use on limited skin areas for a short course (5-7 days) only under medical supervision.
The use of the drug in children aged 1 to 3 years is possible if the expected effect of therapy outweighs the potential risk to the child. In such cases, it is necessary to limit the total duration of treatment and to exclude measures leading to increased resorption and absorption of the steroid (warming, fixing and occlusive dressings). Do not use the drug on the face. In childhood, suppression of the function of the adrenal glands can develop faster. In addition, there may be a decrease in the excretion of growth hormone. When using the drug for a long time, it is necessary to monitor body weight, growth, and the level of cortisol in blood plasma.

Possible increased manifestations of adverse reactions. With prolonged use of the drug in large doses, symptoms of hypercortisolism may appear.
Symptoms: headache, heart failure, hives, rash, severe itching.
Treatment: symptomatic. Cancellation of the drug and seeking medical advice. In severe cases, emergency medical attention is needed. In cases of cutaneous atrophoderma associated with an overdose with topical application of the drug, treatment should be discontinued. As a rule, symptoms will regress within 10-14 days.

Adverse reactions
When using the drug, especially in patients with individual sensitivity to the components of the drug, hyperemia, edema, itching, urticaria, rash, steroid acne, purpura, telangiectasia, burning sensation, irritation, dry skin at the sites of application of the drug, pustules, vesicles, pain may occur, papules at the sites of application, skin cracks; As in the case of topical use of other corticosteroids, side effects may occur (frequency not determined) such as thinning of the skin (skin atrophy), stretch marks, inflammation of the hair follicles (folliculitis) at the site of application, perioral dermatitis, discoloration of the skin, bacterial cellulitis, contact dermatitis and allergic skin reactions to any of the components of the drug. With long-term treatment, it is also possible to develop secondary infectious skin lesions, atrophic changes, hypertrichosis. With prolonged use of the ointment, especially on large affected areas of the skin, hypercortisolism may develop as a manifestation of the resorptive effect of hydrocortisone. In such cases, the drug should be canceled.

Shelf life
2 years. Do not use after the expiry date printed on the package.

Storage conditions
Store Prednizolon in its original packaging at a temperature not exceeding 25 ° C. Keep out of reach of children.