Prednizolon is used for urgent treatment in cases of: a state of shock in case of burns, injuries, operations, intoxication, cardiogenic shocks; allergic reactions, especially in acute and severe forms of allergies – anaphylaxis, blood transfusion shock; cerebral edema, including brain tumors, surgery, radiation therapy, head trauma; bronchial asthma (severe attack), status asthmaticus; systemic connective tissue diseases (lupus erythematosus, rheumatoid arthritis); acute adrenal insufficiency; thyrotoxic crisis; acute hepatitis, hepatic coma; inflammation and prevention of scarring, including chemical burns.
Prednizolon Composition and release form
The main active ingredient is prednisolone.
The drug is sold in the form of tablets, where 1 tablet contains 5 mg of prednisolone.
The considered drug Prednizolon belongs to the group of drugs from the group of glucocorticosteroids, which are used as an anti-inflammatory agent.
The main active ingredient is prednisone. It is a synthetic preparation, dehydrated analogue of hydrocortisone. Produces anti-inflammatory, anti-allergic, immunosuppressive effect. Has the ability to increase the resistance of beta-adrenergic receptors to endogenous catecholamines. It helps to reduce the level of globulin in blood plasma, reduces synthesis and increases the level of catabolism in muscle tissues.
Promotes the redistribution of adipose tissue, enhances the absorption of carbohydrates from the gastrointestinal tract, and causes hyperglycemia. Retains sodium salts in the body. Prevents the formation of scar tissue.
The specified pharmaceutical preparation Prednizolon is used for urgent treatment in cases where an immediate increase in the level of glucocorticosteroids in the body is required, if other means are ineffective.
In particular, when:
- a state of shock in case of burns, injuries, operations, intoxication, cardiogenic shocks;
- allergic reactions, especially in acute and severe forms of allergies – anaphylaxis, blood transfusion shock;
- cerebral edema, including brain tumors, surgery, radiation therapy, head trauma;
- bronchial asthma (severe attack), status asthmaticus;
- systemic connective tissue diseases (lupus erythematosus, rheumatoid arthritis);
- acute adrenal insufficiency;
- thyrotoxic crisis;
- acute hepatitis, hepatic coma;
- inflammation and prevention of scarring, including chemical burns.
The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.
Also contraindicated for:
- stomach ulcer, gastritis, esophagitis, other diseases of the gastrointestinal tract;
- parasitic, fungal, bacterial and other infections;
- pre- and post-vaccination period;
- HIV, AIDS;
- diabetes mellitus, thyrotoxicosis, hypothyroidism, and other diseases of the endocrine system;
- osteoporosis, glaucoma.
It is contraindicated to use before reaching 18 years of age.
Application during pregnancy and lactation
During pregnancy, the use of this drug is contraindicated.
If there is a need to take the drug during lactation, then it should be suspended for the period of treatment.
Method of administration and dosage
This Prednizolon drug is taken orally, after the acute period during which the drug is injected has passed and the drug is switched to oral administration.
The dosage depends on the disease, the patient’s condition.
The starting dose is usually 20 to 30 mg. It is taken 3-4 times a day. The maintenance dosage is 5 to 10 mg per day. The maximum dosage is up to 100 mg per day.
The course of treatment is from 3 to 18 days.
The dosage is reduced gradually.
The duration of treatment, dosage and its correction are determined individually by the attending physician.
Overdose can cause increased side effects.
In case of excessive ingestion, it is recommended to apply symptomatic treatment, to wash the stomach, and to take enterosorbents.
When treating with this drug, side effects may occur in the form of allergic reactions – allergic urticaria, itching, rash, swelling, exanthema.
There are also possible side effects such as:
- diabetes mellitus, edema, dysmenorrhea, amenorrhea, increased blood pressure;
- nausea, vomiting, pancreatitis, stomach ulcer, fluctuations in appetite;
- arrhythmia, thrombosis;
- delirium, euphoria, insomnia, vertigo, convulsions;
- glaucoma, cataracts, loss of vision;
- hypocalcemia, sweating;
- hypernatremia, hypokalemia, myalgia, weakness;
- slowing growth;
- local reactions when administered intravenously;
- exacerbation or development of infections.
Storage conditions and periods
Shelf life – no more than 2 years from the date of issue indicated on the packaging by the manufacturer.
Storage temperature should not exceed 25 ° C.