Prestilol (bisoprolol fumarate) coated tablets 10 mg/10 mg. №30


Prestilol is used for arterial hypertension and / or stable coronary artery disease (in the presence of myocardial infarction, history of revascularization).



Prestilol Composition and form of release
Active ingredients: perindopril (10 mg), bisoprolol fumarate (10 mg).
Available in pill form.

Pharmacological properties
This is a combination antihypertensive drug (lowers blood pressure). Contains perindopril and bisoprolol as active substances. Perindopril acts by suppressing the effect of an angiotensin-converting enzyme that catalyzes the conversion of angiotensin-I into angiotensin-II peptide, which has vasoconstrictor activity. Thus, its stimulating effect on the secretion of aldosterone by the adrenal glands is blocked. Bisoprolol is a highly selective (selective) beta-adrenergic receptor blocker. It suppresses the level of renin in the blood, reduces cardiac activity.

Prestilol is used for arterial hypertension and / or stable form of coronary artery disease (in the presence of myocardial infarction, history of revascularization).

Prestilol should not be used:

  • with allergies to components;
  • with idiopathic, hereditary angineurotic edema;
  • with intolerance to other drugs of the ACE inhibitor group;
  • with angioedema after taking medications in the past;
  • in acute / decompensated heart failure requiring inotropic therapy;
  • with cardiogenic shock;
  • with AV blockade of II or III degree (without an artificial pacemaker);
  • with Short’s syndrome;
  • with SA blockade;
  • with symptomatic bradycardia;
  • with symptomatic arterial hypotension;
  • with severe bronchial asthma;
  • with severe obliterating diseases of peripheral arteries, Raynaud’s syndrome;
  • with metabolic acidosis;
  • with untreated pheochromocytoma.

Application during pregnancy and lactation
This medicine is not prescribed for pregnant women, nursing mothers, or women planning a pregnancy.

Method of administration and dosage
Prestilol is administered orally in a dose of one tablet once a day (preferably before breakfast).

Symptoms: shock, vascular insufficiency, agitation, anxiety, drop in blood pressure, dizziness, fainting, hepatic / renal failure, cough, bradycardia, electrolyte imbalance, arrhythmia, hyperventilation, bronchospasm, hypoglycemia, acute heart failure.
It is recommended to take measures to remove the drug from the body (gastric lavage, intake of enterosorbents). Symptomatic therapy is being carried out.

Side effects
Possible drop in blood pressure, nausea, fatigue, dizziness, diarrhea, headache, muscle spasms, dry cough, angioedema, anemia, leukopenia, change in taste, agranulocytosis, change in voice tone, increased urea levels, liver transaminases, creatinine in plasma, cholestatic jaundice, proteinuria, fainting, palpitations, tachycardia, arrhythmia, bronchitis, bronchospasm, skin rash, thrombocytopenia, rhinitis, conjunctivitis, eosinophilic alveolitis / pneumonia, sinusitis, glossitis, diarrhea, hepatic vascular disease, rituatitis, abdominal pain cholestatic hepatitis, orthostatic reactions, liver failure, alopecia, rash, itching of the skin, psoriasis, urticaria, sweating, angioedema, allergic dermatitis, polymorphic erythema, arthralgia / arthritis, fever, vasculitis, myalgia, photosensitivity, dysfunction, impotence oliguria / anuria, gynecomastia, arthralgia.

Storage conditions and periods
Store Prestilol under normal conditions for no more than 30 months.