Ramizes Com (ramipril) tablets 5 mg/25 mg. №30


Ramizes Com tablets are a combined drug that has antihypertensive and diuretic effects, helps to lower blood pressure, while not increasing the heart rate, as well as the expansion of blood vessels. Increases the excretion of water, chlorine, sodium and potassium from the body.


Composition and form of release
Ramizes Com is available in the form of round, flat tablets, which have a chamfer and a risk with one, inclusions are possible. The main elements in one tablet are ramipril 5 mg and hydrochlorothiazide 25 mg. As additional substances: lactose, magnesium stearate, microcrystalline siliconized cellulose, iron oxide red and yellow, monohydrate, crospovidone, hypromelose. One pack contains 3 blisters, each containing 10 tablets.

Pharmacological properties
Ramizes Com tablets are a combined drug that has antihypertensive and diuretic effects, helps to lower blood pressure, while not increasing the heart rate, as well as the expansion of blood vessels. Increases the excretion of water, chlorine, sodium and potassium from the body.

Indications for use
Ramizes Com tablets are prescribed for the treatment of arterial hypertension, for patients who do not have proper blood pressure control with ramipril or hydrochlorothiazide monotherapy.

Ramizes Com tablets are contraindicated in: renal stenosis, hepatic failure, arterial hypotension, angioedema, hemodynamically unstable conditions, hypokalemia, anuria, hyponatremia, gout, hypercalcemia, electrolyte imbalance, and concomitant treatment with extracorporeal or extracorporeal methods. Also, with personal intolerance to the constituent components and under the age of 18.

Application during pregnancy and lactation
The drug should not be used by women who are planning to have a baby, as well as pregnant and breastfeeding women.

Method of administration and dosage
Treatment with Ramizes Com for arterial hypertension begins with the lowest possible dose. If necessary, the dose is gradually increased until the blood pressure is normalized. The maximum daily dose is 10 mg ramipril and 25 mg hydrochlorothiazide.

  • Patients who have kidney disease, provided that creatinine clearance is between 30 and 60 ml / min, take the lowest dose of the fixed ramipril / hydrochlorothiazide combination. The maximum permissible daily dose for such patients is 5 mg of ramipril and 25 mg of hydrochlorothiazide.
  • For patients in old age, treatment begins with a minimum dose, in the future, dose titration should be carried out more gradually.
  • For patients with impaired liver function, the maximum daily dose is 2.5 mg of ramipril and 12.5 mg of hydrochlorothiazide, treatment should be carried out under the strict supervision of a physician.

In cases where the patient takes diuretics, it is necessary to stop taking diuretics or reduce the dose before starting treatment. The doctor selects and changes the dose for each patient individually.

The drug is taken at the same hour orally once a day, without chewing, drinking plenty of water, Ramizes Kom can be used before and after meals, as well as during meals. The dose of a fixed combination of ramipril and hydrochlorothiazide is selected for each patient personally, depending on the general condition, the patient and what the patient’s blood pressure is.

In case of an overdose with pills, the following are possible: arterial hypotension, bradycardia, shock, cardiac arrhythmias, electrolyte imbalance, impaired consciousness, tachycardia, acute urinary retention, weakness, oliguria, dizziness, muscle spasms, polyuriaanuria, hypokalemia, hyponatremia, alkalesia renal failure. In case of intoxication with the drug, the patient needs to do a gastric lavage, take adsorbents to cleanse the body, take measures to restore stable hemodynamics. Treat symptomatically and to maintain.

Side effects
When taking tablets, side reactions may occur: myocardial ischemia, peripheral edema, tachycardia, arterial hypotension, arrhythmia, decreased blood pressure, a feeling of increased heart rate, fainting, hypoperfusion, Raynaud’s phenomenon, vasculitis, increased urination, vascular stenosis, impaired renal function, increased levels of urea and creatinine, cough, sinusitis, nasal congestion, discomfort and pain in the stomach, bronchitis, indigestion, shortness of breath, dyspepsia, bronchospasm, diarrhea, dry mouth, pancreatitis, vomiting, angioedema, nausea, gastrossritis, constipation, gloss , cholestatic jaundice, stomatitis, hepatitis, liver failure.
Also possible: headache, paresthesia, dizziness, ageusia, tremor, dysgeusia, imbalance, visual impairment, impaired psychomotor functions, hearing impairment, burning sensation, cerebral ischemia, parosmia, conjunctivitis, toxic epidermal necrolysis, tinnitus, rash, hyperhidrosis, pruritus, exfoliative dermatitis, urticaria, onycholysis, dermatitis, photosensitivity reaction, erythema multiforme, pemphigus, Stevens Johnson syndrome, alopecia.
The use of the drug can cause muscle spasms, an increase in the level of potassium in the blood, myalgia, anorexia, loss of appetite, arthralgia, pancytopenia, a decrease in the level of sodium in the blood, eosinophilia, a decrease in the level of hemoglobin, a decrease in the number of leukocytes, erythrocytes, platelets, hemolytic anemia, decreased libido, decreased mood, gynecomastia, anxiety, anxiety, pyrexia, nervousness, sleep disturbances, confusion, drowsiness, asthenia, fatigue.

Storage conditions and periods
Ramizes Com should be stored in a place with temperatures up to + 25 ° C, in its original packaging, out of sight of children. After 2 years from the date of manufacture, the drug cannot be used. Leave is made by prescription.