External and internal hemorrhoids, cracks in the anus, erosion and microtrauma of the anus, anal itching.
Storage Relief Advans
active substance: benzocaine;
1 g of ointment contains benzocaine 200 mg;
Excipients: light mineral oil, white soft paraffin, propylene glycol, methylparaben (E 218), propylparaben (E 216), sorbitan stearate.
Pharmacological properties Relief Advans
Benzocaine reversibly stabilizes the membrane of the neuron, which reduces its permeability to sodium ions. Depolarization of the neuronal membrane is suppressed, and thus blocks the occurrence and conduction of nerve impulses. Thus benzocaine has a pronounced local analgesic effect.
Indication Relief Advans
External and internal hemorrhoids, erosions, cracks, diseases of the rectum, which are accompanied by severe pain, itching, burning in the anorectal area; postoperative period in patients who underwent proctological operations; for anesthesia during diagnostic manipulations.
Hypersensitivity to any component of the drug, including excipients, and to other amide local anesthetics, thromboembolic disease, granulocytopenia.
Use during pregnancy or breastfeeding
During pregnancy, the drug should be used only when absolutely necessary after a careful evaluation by a physician of the benefit to the mother / risk to the fetus or child.
During breastfeeding, a decision should be made to discontinue breast-feeding or to discontinue the drug, taking into account the importance of the drug for the mother.
Method of application and dosage
Adults and children over 12 years of age should use the drug after hygienic procedures. Remove the protective cap from the applicator. Attach the applicator to the tube and squeeze out a small amount of ointment to lubricate the applicator. The ointment is gently applied through the applicator to the affected areas outside or inside the anus up to 4 times a day, especially in the evening, morning or after each bowel movement for 7-10 days.
After each use, rinse the applicator thoroughly and place it in a protective cap.
Do not use if protective coating is missing or damaged.
The efficacy and safety of Relif Advance in children under 12 years of age have not been studied. No data available.
Symptoms of overdose may be related to the pharmacological effects of benzocaine. Its systemic absorption in case of overdose may be manifested by drowsiness, anxiety, arrhythmia, agitation. In severe cases – convulsions, coma, decreased respiratory rate or respiratory failure. There are reports that prescribing drugs that contain benzocaine may cause methemoglobinemia. Symptoms such as cyanosis of the skin, lips and nails, headache, dizziness, shortness of breath (difficulty breathing), weakness, and tachycardia that may occur during treatment may indicate a potentially life-threatening methemoglobinemia that requires immediate medical attention.
Emergency care for overdose and the development of methemoglobinemia is the intravenous administration of methylene blue. Other symptoms of overdose require discontinuation of the drug and symptomatic treatment.
- From the blood and lymphatic system. Methemoglobinemia is possible when using the drug (cyanosis of the skin, lips and nail beds, headache, dizziness, shortness of breath, weakness, tachycardia).
- General disorders and administration site conditions: allergic reactions, including redness, skin rash, pruritus, application site pain, injection site changes (irritation, edema).
- From the skin and subcutaneous tissue: allergic dermatitis, contact dermatitis.
Opening the tube and starting to use the drug does not affect the shelf life, provided it is tightly closed with a cap each time after use. Do not use after the expiry date stated on the package.
Keep out of reach of children at a temperature not exceeding 25 ºC.