Relief Advans (benzocaine) rectal suppositories №12


External and internal hemorrhoids, cracks in the anus, erosion and microtrauma of the anus, anal itching.



Storage Relief Advans
active substance: 1 suppository contains benzocaine 206 mg;
Excipients: cocoa butter, corn starch, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216).

Dosage form
Rectal suppositories.

Pharmacological properties Relief Advans
Benzocaine inversely stabilizes the neuronal membrane, which reduces its permeability to sodium ions. Depolarization of the neuronal membrane is suppressed, and thus blocks the occurrence and conduction of nerve impulses. Thus benzocaine has a pronounced local analgesic effect.

Indication Relief Advans
External and internal hemorrhoids, cracks, erosion and microtrauma in the anus, perianal itching with severe pain. As an anesthetic after proctological surgery.

Hypersensitivity to any of the components of the drug and other amide local anesthetics, thromboembolic disease, granulocytopenia.

Method of application and dosage
The drug Relief Advans should be used after hygienic procedures. Inject 1 suppository into the anus in the morning, after each bowel movement and at bedtime. Daily dose – no more than 4 times a day. Regular use of the drug provides a lasting therapeutic effect, relieves the symptoms of hemorrhoids. The duration of treatment is usually 1 week. If necessary, it can be extended for up to 3 weeks or more (after consulting a doctor).

For children under 12 years of age, the drug is prescribed by a doctor only when absolutely necessary.

Symptoms of overdose may be related to the pharmacological effects of benzocaine. Its systemic absorption in case of overdose may be manifested by drowsiness, anxiety, arrhythmia, agitation, in severe cases, convulsions, coma, decreased respiratory rate or respiratory failure. There are reports that prescribing products containing benzocaine may cause methemoglobinemia. Symptoms such as cyanosis of the skin, lips and nails, headache, dizziness, shortness of breath (difficulty breathing), weakness, and tachycardia that may occur during treatment may indicate a potentially life-threatening methemoglobinemia that requires immediate medical attention.
In cases of significant excess of the recommended single and daily doses of shark liver oil, there may be a tendency to accelerated blood clotting.
Emergency care for overdose and the development of methemoglobinemia is the intravenous administration of methylene blue. Other symptoms of overdose require discontinuation of the drug and symptomatic treatment.

Side effects:

  • From the blood and lymphatic system. When using the drug may be methemoglobinemia (cyanosis of the skin, lips and nail beds, headache, dizziness, shortness of breath, weakness, tachycardia);
  • General disorders and administration site conditions: allergic reactions, including redness, skin rash, itching; changes in the injection site (irritation, edema, pain);
  • From the skin and subcutaneous tissue: allergic dermatitis, contact dermatitis.

The other ingredients methyl parahydroxybenzoate and propyl parahydroxybenzoate may cause allergic reactions (possibly delayed).

Expiration date
2 years.
Do not use the drug if the protective plastic shell is missing or damaged.

Storage conditions
Store at a temperature not exceeding 25 oC. Keep out of reach of children.