In complex therapy: tuberculosis of different localization, tuberculosis meningitis, as well as atypical mycobacteriosis; infectious and inflammatory diseases of non -tuberculosis nature caused by pathogens sensitive to the drug (including severe forms of staphylococcal infection, leprosy, legionellosis, brucellosis); asymptomatic carrier of N. meningitidis for the elimination of meningococci from the nasopharynx and prevention of meningococcal meningitis.
Composition and form of release
The active ingredient is rifampicin. Comes on sale in capsules (0.15 grams).
An antibiotic that is mainly used to treat tuberculosis of various organs. It is also effective for the treatment of various forms of leprosy, inflammatory and infectious diseases of the lower respiratory tract, which are caused by multi-resistant staphylococci, as well as osteomyelitis, urinary and biliary tract, the acute phase of gonorrhea, and other pathogens that rifampicin can counteract.
It is able to completely or partially destroy the rabies virus, rabies encephalitis, therefore it is actively used in the incubation treatment of these diseases. Shows activity against gram-positive (staphylococci) and gram-negative (menningococci, gonococci) cocci.
Unfortunately, microorganisms quickly develop resistance (resistance) to rifampicin, so it is advisable, if possible, not to abuse its prescription for the treatment of diseases not caused by tuberculosis.
Contraindicated for use in children – infants, patients with jaundice, hepatitis, kidney disease, especially if their excretory function is reduced. Not applicable in case of allergy to rifampicin.
It is contraindicated to administer the drug intravenously if the patient suffers from pulmonary heart failure or phlebitis.
Application during pregnancy and lactation
Method of administration and dosage
In the form of capsules, the drug is taken on an empty stomach, half an hour to an hour before eating.
For tuberculosis, it is enough to take 0.45 grams 1 time per day. With a body weight of more than 50 kg, let us take 0.6 grams per day (4 capsules). If the patient does not tolerate the drug very well, the daily dose can be taken, divided into 2 doses – morning and evening, after 12 hours.
Intravenous administration (drip) is acceptable for adult patients. To do this, 1 ampoule of rifampicin is diluted in 2.5 water for injection and then brought to 125 ml of glucose solution (5%). In severe conditions, a single dose of 0.6 grams is permissible.
Basically, the intravenous form is taken if the patient has an acute progressive or widespread form of pulmonary tuberculosis, severe purulent-septic processes (the formation of abscesses in the tissues of the body), that is, in cases when it becomes necessary to create a high concentration of rifampucin in the blood in a short time, or if the patient cannot take capsules orally for various reasons (difficulty swallowing, side effects from the gastrointestinal tract).
The duration of therapy with intravenous administration can last up to 1 month. General therapy for tuberculosis with this drug can last up to 1 year, while the form may vary depending on the patient’s condition.
Since the patient quickly develops drug resistance, it is advisable to intersperse it with other anti-TB drugs.
In the treatment of leprosy, rifampicin is also taken once a day, 2-3 capsules at a time. The treatment lasts 3-6 months. It is permissible to repeat treatment courses with a break of 1 month.
Acute gonorrhea is treated with a single dose of 9 grams of the drug at once. It is possible to repeat the appointment in a day.
To prevent rabies, the drug is taken within 5-7 days at 0.45-0.6 grams. In especially severe cases, up to 0.9 grams. Let’s admit taking a daily dosage in 2-3 doses.
Overdose is manifested by symptoms of severe intoxication, dyspeptic symptoms, renal, hepatic failure. Tachycardia, arrhythmia, convulsions, cardiac arrest, and even death are possible. Therefore, it is necessary to conduct gastric lavage as soon as possible and prescribe symptomatic therapy.
Intolerance reactions are rare. Possible dyspeptic disorders, disruption of the pancreas, liver, reduces pressure if too rapid intravenous administration.
Since the drug itself is painted in a bright red-brown color, urine, sputum discharge, and tears acquire the same shade.
Storage conditions and periods
Stored for up to 2 years at temperatures up to 25 ° C.