Risset (risperidone) coated tablets 4 mg. №60


Treatment of schizophrenia and other psychiatric disorders, including supportive therapy in patients who have had a response to therapy, in order to prevent relapse; short term treatment of severe aggression or severe mental symptoms in patients with dementia if there is a threat of harm to themselves or others; treatment of manic episodes in bipolar disorders (auxiliary therapy in combination with normotimics as initial treatment or monotherapy for a period of up to 12 weeks); symptomatic treatment of social behavior disorders, defiant opposition disorders, or other social behavior disorders in children, adolescents, and adults with lower-than-average mental development or mental retardation who have manifestations of destructive behavior (impulsivity, autoagression); symptomatic treatment of autistic disorders in children aged 5 years and older, whose symptoms range from hyperactivity to irritability (including aggression, self-harm, anxiety, and pathological cyclical actions).

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Composition and form of release
Active ingredient: risperidone (4 mg).
Risset is produced in pill form.

Pharmacological properties
It is an antipsychotic drug (neuroleptic). The active substance selectively (selectively) blocks 5-HT2-serotonergic, D2-dopaminergic receptors of the central nervous system, as well as α1-adrenergic, to a lesser extent, α2-adrenergic and H1-histamine receptors. Eliminates hallucinations, delusions, automatism, reduces aggressiveness, fear.

Risset is used:

  • with schizophrenia with pronounced productive (aggressiveness, delirium, hallucinations, thought disorders) or negative symptoms (poor speech, social and emotional detachment);
  • in acute / chronic psychoses with pronounced productive or negative symptoms;
  • in other psychotic conditions with affective symptoms.

Risset does not apply:

  • if you are allergic to risperidone;
  • with intolerance to excipients.

Application during pregnancy and lactation

Method of administration and dosage
Risset is used internally.
The standard dose for adults is 2 mg / day, on the next day the dose is increased to 4 mg / day, on the 3rd day – up to 6 mg / day in one or two doses. In the future, an individual maintenance dose is selected (usually 4–8 mg / day).
The maximum dose is 16 mg / day.
Elderly patients or patients with severe hepatic / renal impairment should be halved.

Symptoms: drowsiness, excessive sedation, tachycardia, extrapyramidal disturbances, instability of blood pressure.
Therapeutic measures: gastric lavage, the appointment of sorbents, support of the respiratory and cardiovascular systems, control of electrolyte balance, regulation of the acid-base state.

Side effects:

  • Neurological disorders: hyperthermia of central origin, drowsiness, headache, fainting, confusion, akathisia, extrapyramidal disorders (hypokinesia, akinesia, tremor, muscle rigidity), sleep disturbances, insomnia, depression, seizures, neuroleptic malignant syndrome (shortness of breath) tachypnea, convulsions, tachycardia, arrhythmia, unstable blood pressure, hyperthermia, increased sweating, severe muscle stiffness, involuntary urination, pallor of the skin, fatigue, weakness), tardive dyskinesia.
  • Cardiovascular disorders: decrease / increase in blood pressure (including orthostatic hypotension), reflex tachycardia, hypertension, stroke.
  • Digestive disorders: constipation, abdominal pain, vomiting, dysphagia, nausea.
  • Dermatological disorders: hyperpigmentation, xeroderma, photosensitivity.
  • Endocrine disorders: hyperglycemia, hyperprolactinemia, galactorrhea, dysmenorrhea, gynecomastia, amenorrhea.
  • Genitourinary disorders: priapism, anorgasmia, erectile dysfunction, ejaculation, dysuria, urinary incontinence, polyuria.
  • Hematological disorders: neutro-, thrombocytopenia, thrombocytopenic purpura, anemia.
  • Ophthalmic disorders: violation of accommodation, xerophthalmia, decreased visual acuity.
  • Others: peripheral edema, weight gain, rhinitis, manifestations of allergies, incl. angioedema, skin rashes, pain in joints / bones / muscles.

Storage conditions and periods
Store Risset in its original packaging. Optimal temperature conditions: up to +25 degrees. Best for 30 months after production (see the date on the packaging).