Symptomatic treatment of moderate to high intensity acute pain in cases where oral administration of the drug is not appropriate, for example, postoperative pain, renal colic and lower back pain.
Rotalfen Composition and form of release
The main active ingredient of the drug is dexketoprofen. The auxiliary components are: ethanol, sodium chloride, sodium hydroxide, water for injection.
This drug is produced in the form of an injection solution, packaged in 2 milliliter ampoules, which contain 50 milligrams of the main active ingredient.
In this case, 1 milliliter of the drug contains 25 mg of the main active ingredient – dexketoprofen.
This drug belongs to the group of non-steroidal anti-inflammatory and antirheumatic drugs, and its main active ingredient, dexketoprofen trometamol, belongs to the derivatives of propionic acid.
The main active ingredient is the propionic acid salt, exhibiting the properties of an analgesic, anti-inflammatory and antipyretic effect.
The action of the drug is due to its ability to reduce the synthesis of prostaglandins due to inhibition of the enzyme, or, more precisely, the group of cyclooxygenase enzymes.
The property to inhibit the synthesis of prostaglandins also affects other mediators of the inflammatory process, in particular, kinins. It also affects the main mechanism of action of a given drug, in particular its analgesic (pain relieving) properties.
This drug is a non-steroidal anti-inflammatory drug that is used to treat symptomatic pain of moderate to high intensity when oral administration is not possible or desirable.
In particular, it is used if it is necessary to relieve pain in:
- postoperative pain;
- renal colic;
- back pain.
The duration of the action of the drug is about 8 hours.
Using this drug can reduce the need for opiates.
If there is a need to take morphine, then if it is taken simultaneously with dexketoprofen, the dose of morphine is reduced by 30-45%.
Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
Also, use is contraindicated for:
- attacks of bronchial asthma;
- gastric ulcer and 12 duodenal ulcer in the acute phase;
- gastrointestinal, other bleeding, history of perforation;
- Crohn’s disease, ulcerative colitis;
- severe heart failure;
- renal and / or hepatic failure of moderate and severe degree;
- hemorrhagic diathesis, other blood clotting disorders;
- use for the purpose of neuraxial administration (intrathecal or epidural).
Application during pregnancy and lactation
This drug is contraindicated for use starting from the 6th month of pregnancy, as well as when planning a pregnancy.
During treatment with this drug, breastfeeding should be discontinued.
Method of administration and dosage
The drug Rotalfen is intended for intramuscular or intravenous administration (bolus or infusion, as decided by the doctor).
The dose is selected by the attending physician, based on the individual characteristics of the body and the course of the disease of each patient.
Average dosage: – 50 mg, every 8-12 hours. If necessary, after 6 hours.
A maximum of 150 mg of dexketoprofen can be administered per day.
This drug is not intended for systemic use, it can be administered for no more than 2 days in a row, in case of acute pain. If possible, the transfer to the oral form should be carried out as early as possible. Simultaneous administration with opioid analgesics (in the same recommended average dosage as monotherapy) is acceptable.
No dose adjustment is required in elderly patients. In case of impaired renal or liver function, the dose is reduced to 50 mg per day.
Intramuscular injection is performed deep into the gluteus muscle.
Intravenous bolus injection – 2 ml of solution is injected over a minimum of 15 seconds.
Intravenous drip – administered over 10-30 minutes. To prepare an infusion solution, sodium chloride solution, glucose, Ringer’s lactate solution are used. It can be mixed with dopamine, heparin, lidocaine, morphine, pethidine and theophylline.
Do not mix with promethazine or pentazocine.
The dosage has not been fixed at this time.
In case of an overdose, such drugs usually cause disorders of the digestive system, in particular:
- abdominal pain.
A disorder of the nervous system may also occur in the form of:
Treatment of symptoms and dialysis are recommended.
Therapy with this drug can cause:
- headache, nausea, vomiting;
- chills, asthenia, dermatitis, rash, urticaria, vertigo, dermatitis;
- arterial hypotension, arterial hypertension, thrombophlebitis, hot flashes;
- stomach ulcer, hepatitis, laryngeal edema, perforation;
- acne (acne), nephritis.
Storage conditions and periods
Shelf life is 4 years. Store at a temperature not exceeding 25 ° C.
The finished solution retains its properties during the day at a storage temperature of 2 to 8 ° C.