Roxipim (cefepime) powder for solution for injections 1g. №1 vial + solvent 10 ml. №1

$33.10

Large. Infections caused by sensitive to the drug microflora: respiratory tract infections, including pneumonia, bronchitis; skin and subcutaneous tissue infections; intraabdominal infections, including peritonitis and biliary tract infections; gynecological infections; septicaemia. Empirical therapy of patients with neutropenic fever. Prevention of postoperative complications in intraabdominal surgery. Children. Pneumonia. Urinary tract infections, including pyelonephritis. Skin and subcutaneous tissue infections. Septicaemia. Empirical therapy of patients with neutropenic fever. Bacterial meningitis.

Category: Manufacturer: Turkey

Description

Composition and form of release
Active ingredient: cefepime (1000 mg / vial).
Roxipim is produced in the form of a solution for injection.

Pharmacological properties
It is a 4th generation cephalosporin antibiotic that has a bactericidal effect (kills bacteria). Active against many gram-positive / negative bacteria.

Indications
Roxipim is prescribed for adults:

  • with respiratory tract infections (sinusitis, pneumonia, bronchitis);
  • with infections of the skin, subcutaneous tissue;
  • with intra-abdominal (intra-abdominal) infection, incl. with peritonitis, infections of the biliary tract;
  • with gynecological infection;
  • with septicemia (blood poisoning);
  • for empiric therapy (with an unknown diagnosis) of patients with neutropenic fever;
  • to prevent postoperative complications in intra-abdominal surgery.

Roxipim is prescribed for children:

  • with pneumonia;
  • with infections of the skin, subcutaneous tissue;
  • with urinary tract infection, incl. with pyelonephritis;
  • with septicemia (blood poisoning);
  • for empiric therapy (with an unknown diagnosis) of patients with neutropenic fever;
  • with bacterial meningitis.

Contraindications
Roxipim is contraindicated:

  • with intolerance to the components;
  • with allergies to cephalosporins, penicillins, and other β-lactam antibiotics.

Roxipim is used with caution in diseases of the digestive tract (especially colitis).

Application during pregnancy and lactation
Only when prescribed by a doctor.
Small amounts of cefepime pass into breast milk, so feeding is stopped.

Method of administration and dosage
Roxipim is administered parenterally. For adults, it is usually administered intravenously or intramuscularly at a dose of 1000 mg at intervals of 12 hours. For life-threatening infections, 2000 mg is indicated every 8-12 hours.
The standard duration of treatment is 7-10 days.

Overdose
Symptoms: the development of encephalopathy (hallucinations, impaired consciousness, stupor, coma, myoclonus, epileptiform seizures, neuromuscular excitability).
Treatment: stop drug administration, carry out symptomatic therapy, apply hemodialysis.

Side effects:

  • Immune disorders: allergies, including anaphylaxis, angioedema, anaphylactic shock, Stevens-Johnson syndrome, Lyell’s syndrome.
  • Respiratory disorders: shortness of breath, cough, sore throat.
  • Cardiovascular disorders: tachycardia, vasodilation.
  • Digestive disorders: nausea, dyspepsia, oral candidiasis, perverted taste, diarrhea / constipation, pseudomembranous colitis, abdominal pain.
  • Neurological disorders: dizziness, paresthesia, insomnia, headache, anxiety, convulsions, hallucinations, impaired consciousness, stupor, coma.
  • Hepatobiliary disorders: cholestatic jaundice, hepatitis.
  • Skin changes: rashes, itching, hives.
  • Others: asthenia, sweating, fever, vaginitis, erythema, chest pain, back pain, peripheral edema, genital itching, candidiasis, renal failure, transient leukopenia, neutropenia, thrombocytopenia, agranulocytosis, increased AST / ALT, ALP, urea, creatinine , bilirubin, anemia, eosinophilia, increased partial thromboplastin time, prothrombin time, positive Coombs test result without hemolysis, bleeding.
  • Respiratory disorders: dyspnea.
  • Local changes: with intravenous administration – phlebitis, tissue inflammation; with intramuscular injection – pain, inflammation.

Storage conditions and periods
Roxipim should be stored in its original packaging for no more than 2 years. Temperature conditions: not higher than 30 ° С. The solution must not be frozen.