Rozalin (dorzolamide) eye drops solution 20 mg/ml. 5 ml. vial №1 with capel.


Treatment of increased intraocular pressure in patients with: ocular hypertension; glaucoma; pseudoexfoliative glaucoma; as an adjunct therapy for beta-blocker treatment or as monotherapy when beta- blocker treatment has not been successful or beta- blockers are contraindicated.

Category: Manufacturer: Greece


Rozalin Composition and form of release
The main active ingredient of the drug is dorzolamide. As an auxiliary component used: benzalkonium chloride, sodium hydroxide, sodium citrate, dihydrate, hydroxyethyl cellulose, water for injection.
The drug is produced in the form of eye drops, and is sold poured into dropper bottles, 5 ml in a bottle.
1 ml of the drug contains 20 mg of dorzolamide in the form of dorzolamide hydrochloride.

Pharmacological properties
Ophthalmic drug, which belongs to the group of antiglaucoma drugs and miotic drugs.
The main active ingredient of the drug – dorzolamide – is a powerful inhibitor of human carbonic anhydrase II. Once applied topically, it effectively reduces intraocular pressure, both associated and non-glaucoma.
Increased intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucoma narrowing of the visual field.
The positive characteristics of dorzolamide include its property, with a decrease in intraocular pressure, not to cause the development of side effects inherent in other miotics, such as night blindness, accommodative spasm, or pupil constriction.
The drug also has no or little effect on blood pressure and / or heart rate.
Unlike oral drugs – carbonic anhydrase inhibitors, in the case of topical application, dorzolamide acts directly in the human eye, while significantly lower concentrations are required, and therefore such use is accompanied by less systemic exposure.

Rozalin Indications
It is used as a medicine that is used in the treatment of:

  • increased intraocular pressure;
  • open-angle glaucoma;
  • pseudoexfoliative glaucoma;
  • other types of secondary open-angle glaucoma.

The main active ingredient of the drug, dorzolamide, has shown its effectiveness both in monotherapy and when used in combination with local beta-blockers. Dorzolamide reduced intraocular pressure throughout the day, and this effect persisted for a significant time.
In terms of its effectiveness, this drug (after long-term monotherapy) showed its similarity with betaxolol and only to some extent lower than timolol.

Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
In addition, the use of this drug is contraindicated if the patient has:

  • severe renal dysfunction;
  • hyperchloremic acidosis;
  • allergy to sulfa drugs.

Simultaneous use with drugs that inhibit the production of aqueous liquid after filtration measures is not recommended, as this can cause detachment of the choroid.
It is not used in pediatrics.

Application during pregnancy and lactation
This drug is not recommended for use during pregnancy.
If there is a need to use this drug during breastfeeding, then it is better to suspend lactation for this period.

Method of administration and dosage
The drug Rosalin is used 1 drop in each affected eye (in the conjunctival sac), three times a day.

With combined or additional therapy, 1 drop is administered twice a day.
In order for the drug to be better absorbed, you should immediately after instillation, close your eyes, slightly press your eyelids and hold it for a few seconds.
If there is a need to replace another local antiglaucoma drug with dorzolamide, you should suspend treatment with this drug and start using this drug the next day.
If there is a need to use several topical ophthalmic agents, they should be administered at intervals of 10 minutes.
Before introducing the drug into the eye, wash your hands thoroughly and avoid contact of the dropper tip with the eye or skin during instillation.
If these precautions are violated, the drug may be contaminated with foreign bacteria, and the infection may subsequently get into the eyes, which can have dire consequences.

Overdose with this drug was observed extremely rarely. In rare cases, overdose has been observed:

  • drowsiness (with accidental oral ingestion);
  • nausea, dizziness, headache;
  • feeling tired;
  • atypical dreams;
  • dysphagia.

Disorders of the central nervous system, manifestations of asthenia, electrolyte disturbances are also possible.
Symptomatic treatment is recommended. It is necessary to control the content of electrolytes, in particular potassium, in blood plasma, monitor blood pH.

Side effects
Adverse reactions have been observed with this drug:

  • headache, paresthesia, dizziness;
  • burning and tingling in the eyes when the drug is injected;
  • external punctate keratitis, lacrimation, blepharitis, conjunctivitis;
  • itchy eyes, irritation of the eye mucosa, blurred vision, iridocyclitis;
  • clumping of the eyelids, rapidly passing hyperopia;
  • nosebleeds, nausea, bitterness in the mouth, sore throat;
  • contact dermatitis, toxic epidermal necrolysis;
  • urolithiasis disease;
  • asthenia, fatigue;
  • hives, itching, rash, shortness of breath;
  • angioedema, bronchospasm.

If you experience any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.

Storage conditions and periods
Stored for up to 2 years at a temperature not exceeding 25 ° C.
After opening, the contents of the bottle retain their properties for 4 weeks.