Rozvator (rosuvastatin) coated tablets 10 mg. №28


Treatment of hypercholesterolemia Adults, adolescents and children over 10 years of age with primary hypercholesterolemia (type IIA, including heterozygous familial hypercholesterolemia) or mixed dyslipidemia (type IIB) as an adjunct to the diet, when compliance with the diet and the use of other non-medicinal means (for example, exercise, weight loss) is insufficient. In homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering treatments (for example, LDL apheresis) or in cases where such treatment is inappropriate. Prevention of cardiovascular disorders Prevention of significant cardiovascular disease in patients who are estimated to be at high risk of a first case of cardiovascular disease, as an adjunct to correcting other risk factors.

Category: Manufacturer: India


Rozvator Composition and form of release
Active ingredient: rosuvastatin.
The Rоzvator is produced in the form of tablets (10 mg).

Pharmacological properties
This is a remedy that corrects fat metabolism. The active ingredient selectively and competitively inhibits the HMG-CoA reductase enzyme, which catalyzes the conversion of HMG-CoA into a cholesterol precursor in the liver. Promotes an increase in the number of LDL receptors on the surface of liver cells, increasing catabolism and seizure. It also slows down the production of VLDL, thereby reducing the total content of “bad fats” in the blood.

Rozvator Indications
The distributor is appointed:

  • with homozygous hereditary hypercholesterolemia – as an addition to diet, other lipid-lowering pharmaceuticals;
  • for the treatment of primary hypercholesterolemia (type IIa, including heterozygous hereditary hypercholesterolemia);
  • for the treatment of mixed dyslipidemia (type IIb) – as an addition to the diet when non-pharmacological methods are ineffective;
  • for the prevention of cardiovascular complications;
  • to reduce the risk of developing severe cardiovascular complications in adults at high risk of developing them.

You cannot assign a Rоzvator:

  • with intolerance to the components of the drug;
  • with hepatobiliary diseases in the active phase;
  • with chronic kidney disease at stages 4-5 (creatinine excretion rate <30 ml / minute);
  • during pregnancy / lactation, planning pregnancy;
  • with pathology of muscle tissue;
  • while taking cyclosporine;
  • with a predisposition to myopathy, rhabdomyolysis.

Application during pregnancy and lactation
Not applicable.

Method of administration and dosage
The rosvator is taken orally whole, without chewing, with water, regardless of the meal.
The standard starting dose for the treatment of hypercholesterolemia is 5 mg or 10 mg once a day. If necessary, it is allowed to increase the dose after 4 weeks. Due to the high likelihood of side effects, increasing the dose to 40 mg should be considered only in patients with severe hypercholesterolemia, a high risk of cardiovascular complications (for example, hereditary hypercholesterolemia), when it was not possible to achieve the target values ​​when using lower doses.
For the prevention of cardiovascular complications, 20 mg per day is indicated.

Symptomatic therapy, control of hepatic parameters, CPK level is recommended.

Side effects:

  • Blood test changes: thrombocytopenia.
  • Immune disorders: allergies, including angioedema.
  • Endocrine disorders: diabetes mellitus.
  • Mental disorders: depression.
  • Neurological disorders: headache, polyneuropathy, insomnia, dizziness, peripheral neuropathy, amnesia, nightmares.
  • Respiratory disorders: shortness of breath, cough.
  • Digestive Disorders: Pancreatitis, abdominal pain, nausea, constipation / diarrhea.
  • Hepatobiliary disorders: jaundice, hepatitis, increased activity of liver transaminases.
  • Dermatological disorders: rash, Stevens-Johnson syndrome, urticaria, pruritus.
  • Musculoskeletal disorders: myalgia, rhabdomyolysis, myopathy, myositis, arthralgia, tendon rupture, immune-mediated necrotizing myopathy.
  • Urinary disorders: hematuria.
  • Sexual disorders: gynecomastia.
  • General disorders: edema, asthenic syndrome.

Storage conditions and periods Rozvator
It is required to store the Razvator at room temperature (15-30 ° С) for no more than 2 years.