Sangyva (chlorobutanol hemihydrate, choline salicylate, hexetidine) solution for the oral cavity 100 ml. vial


Antibacterial and analgesic agent for local treatment of diseases of the oral mucosa and oropharynx.

Category: Manufacturer: Ukraine


Sangyva Composition
active ingredients: chlorobutanol hemihydrate, choline salicylate, hexetidine;
1 ml of solution contains: hexetidine 1.0 mg; choline salicylate 5.0 mg; chlorobutanol hemihydrate, in terms of chlorobutanol 2.5 mg;
excipients: sodium saccharin, ethanol 96%, polysorbate 20, levomenthol, anise oil, lemon oil, lime oil, eucalyptus oil, methyl salicylate, citric acid monohydrate, purified water.

Dosage form. Oral solution.

Sangyva Pharmacological properties
The action of the drug is due to three active components.
Antibacterial and antifungal activity
Hexetidine has an antibacterial effect on both gram-positive and gram-negative strains of microorganisms, both aerobic and anaerobic.
In general, hexetidine has a bacteriostatic effect on aerobic strains, while the bactericidal effect is weak. Heksetidine has a pronounced bactericidal effect on anaerobic strains. The mechanism of action is a competitive action with thiamine: the structure of hexetidine is similar to the structure of thiamine, which is necessary for the growth of microorganisms.
Anti-inflammatory activity
Choline salicylate has analgesic, antipyretic and anti-inflammatory effects. Used to treat diseases of the oral cavity.
Anesthetic activity
Chlorobutanol has an analgesic effect. It can be used, in particular, in otolaryngology (nasal drops, rinses) and in dental practice (applications and irrigation). Classically it can be used as an anesthetic.

Sangyva Indications
Topical treatment of oral infections. Postoperative care in dentistry.


  • Hypersensitivity to any component of the drug.
  • Atrophic pharyngitis.
  • Bronchial asthma or any other respiratory diseases associated with existing airway hypersensitivity.

Method of administration and dosage
Use as a topical mouth rinse.
For one mouth rinse for adults and children from 6 years of age: place the drug in a measuring cup to the 10 ml mark and bring up to the 50 ml mark with warm water or dissolve 2 teaspoons of the drug in ¼ glass of warm water.
From 2 to 4 rinses per day.
Do not swallow.
The course of treatment is 5 days.

Do not use in children under 6 years of age.

There have been no reports of drug overdose.
Through the absorption of a sufficient amount of solution in the oral cavity, alcohol intoxication may occur due to the content of ethyl alcohol.
The concentration of hexetidine in a drug is not toxic if the drug is used as directed.
Acute alcohol intoxication is unlikely to occur. If a child swallows a large dose of the drug, alcohol intoxication may occur due to the content of ethyl alcohol.
There were no cases of excessive use of hexetidine, which led to the occurrence of allergic reactions.
Overdose treatment is symptomatic but rarely necessary. If a child swallows the contents of the bottle, consult a doctor immediately. It is necessary to consider the possibility of gastric lavage within 2 hours after swallowing and take measures to eliminate signs of alcohol intoxication.

Side effects:

  • From the respiratory system, chest and mediastinal organs: cough, shortness of breath.
  • From the gastrointestinal tract: dry mouth, dysphagia, enlargement of the salivary glands, pain when swallowing. If the drug is accidentally swallowed, gastrointestinal disturbances may occur, especially nausea and vomiting.
  • From the side of the nervous system: ageusia, dysgeusia, change in taste sensations within 48 hours (the sensation of “sweet” can change twice to the sensation of “bitter”).
  • From the immune system: hypersensitivity reactions, including urticaria, angioedema, laryngospasm, bronchospasm.
  • From the skin and subcutaneous tissue: allergic contact dermatitis, skin reactions (rash).
  • General disorders and reactions at the injection site: local reactions – reversible discoloration of teeth and tongue; sensitivity of the mucous membrane (burning, numbness); irritation (soreness, feeling of heat, itching) of the tongue and / or oral mucosa; decreased sensitivity; paresthesia of the mucous membrane; inflammation; bubbles; the occurrence of ulcers on the mucous membrane, a sore throat, swelling at the point of contact, dryness of the nasal / throat mucosa.

Shelf life
1.5 years.

Storage conditions
Store in its original packaging at a temperature not exceeding 25 ° C. Do not freeze.
Keep out of the reach of children.