Sanorin (naphazoline nitrate) nasal drops emulsion 0.1% 10 ml. vial


Manufacturer: Czech Republic

Acute rhinitis. As an adjunct to inflammation of the paranasal sinuses and middle ear.


Sanorin (naphazoline nitrate) nasal drops emulsion 0.1% 10 ml. vial


active ingredient: naphazoline nitrate;

1 ml of emulsion contains naphazoline nitrate 1 mg;

excipients: boric acid, ethylenediamine, cetyl alcohol, methylparaben (E 218), eucalyptus oil, polysorbates, cholesterol, light mineral oil, purified water.

Dosage form

Nasal drops, emulsion.

Basic physical and chemical properties: white, easily shaken emulsion.

Pharmacological group

Decongestants and other drugs for topical use in diseases of the nasal cavity. Sympathomimetics.
Code ATX R01A A08.

Pharmacological properties

Naphazoline is a drug that stimulates the sympathetic nervous system and acts on α-adrenoceptors, has minimal effect on β ‑ adrenoceptors. Due to the vasoconstrictive effect, edema, hyperemia, and exudation are reduced, which facilitates nasal breathing in rhinitis. Nafazolin promotes the opening and expansion of the outlet ducts of the paranasal sinuses and Eustachian tubes, which improves the outflow of secretions and prevents the deposition of bacteria.
The therapeutic effect of intranasal use occurs within 5 minutes and lasts 4-6 hours.


Acute rhinitis. As an aid in inflammation of the paranasal sinuses and middle ear. To reduce mucosal edema during diagnostic intervention.


Hypersensitivity to any components of the drug.
Dry inflammation of the nasal mucosa.
Do not use in children under 15 years.

Method of application and dosage

Adults and children over 15 years of age should instill 1–3 drops of emulsion in each nasal passage 2-3 times a day.
The interval between instillation should be at least 4 hours.
Sanorin emulsion is not recommended to use the drug for more than 5 days.
If nasal breathing is facilitated, use can be stopped earlier.
Sanorin emulsion can be re-applied only after a few days.
For diagnostic purposes, instill 3-4 drops in each nasal passage.
In case of nasal bleeding, you can put a cotton swab dipped in the drug in the nasal passage.
Instill the drug into each nasal passage, tilting the head back slightly. When instilling in the left nasal passage, you should slightly tilt your head to the left, and when instilling in the right nasal passage, tilt your head to the right.


Sanorin emulsion use for children over 15 years.


Overdose or accidental ingestion of the drug may cause systemic side effects: nervousness, sweating, headache, tremor, tachycardia, palpitations, hypertension. Cyanosis, nausea, fever, spasms, cardiac arrest, pulmonary edema, mental disorders, pale skin, heart attack may occur.
The depressant effect on the central nervous system is manifested by such symptoms as a decrease in body temperature; bradycardia; increased sweating; drowsiness; shock similar to antihypertensive; apnea; coma. The risk of overdose increases in children who are more vulnerable to adverse effects than adults.
Treatment is symptomatic.

Side effects

When used in the recommended doses, Sanorin is usually well tolerated. In patients with hypersensitivity, the drug may occasionally cause burning and dryness of the nasal mucosa. In isolated cases, a feeling of severe nasal congestion may occur.
Only in isolated cases there is a systemic side effect (most often in case of overdose):

  • from the immune system: allergic reactions, including Quincke’s edema, burning;
  • from the nervous system: nervousness, headache, tremor;
  • from the cardiac system: tachycardia, palpitations;
  • from the vascular system: hypertension;
  • from the skin and subcutaneous tissue: increased sweating.

Prolonged (longer than 5 days for adults and longer than 3 days for children) or frequent use of the drug can lead to addiction – sanorinism, accompanied by intense swelling of the nasal mucosa that occurs in a relatively short period of time after application. Prolonged use of the drug can damage the epithelium of the mucous membrane, inhibit the activity of the epithelial cilia and cause irreversible damage to the mucous membrane and the development of dry rhinitis.