Secrepat Forte (dihydroxyaluminium aminoacetate; aluminum hydroxide, dry gel) tablets №50


For the symptomatic treatment of pain and heartburn in diseases of the gastrointestinal tract, such as gastric ulcer, duodenal ulcer, gastroesophageal reflux disease, dyspepsia, acute and chronic gastritis with increased or normal secretion. Irritation of the stomach lining caused by Smoking or dietary disorders (alcohol, coffee, sweets, flour products, etc.). As a preventive measure for long-term use of non-steroidal anti-inflammatory drugs, glucocorticoids and other ulcerogenic agents.

Category: Manufacturer: Spain


Secrepat Forte Storage
active substance: dihydroxyaluminum aminoacetate; aluminum hydroxide, dry gel; calcium carbonate; magnesium trisilicate hydrated;
1 tablet contains: aminoacetate dihydroxyaluminum – 400 mg; aluminum hydroxide, dry gel – 100 mg; calcium carbonate – 150 mg; hydrated magnesium trisilicate – 50 mg;
Excipients: glycine, magnesium stearate, essence (anise or mint), polysorbate 80, sodium saccharin, sucrose

Dosage form
Chewable tablets with anise or mint flavor.

Pharmacological properties
Sekrepat forte is a combined balanced antacid drug for heartburn and stomach pain. Reduction of pain and heartburn is provided by the effects of the components that are part of the drug.
Calcium carbonate acts a few minutes after ingestion, neutralizing hydrochloric acid.
Magnesium trisilicate due to the floating effect promotes the formation on the surface of the gastric contents of the antacid film, which covers the wall of the esophagus during reflux. Aluminum salts (dihydroxyaluminum aminoacetate and aluminum hydroxide) in the composition of the Secret forte have acid-neutralizing, enveloping, adsorbing action, maintaining a pH of about 4. The cytoprotective effect of aluminum salts is due to the ability to activate its own protective factors, including the synthesis of prostaglandins, which stimulate the secretion of mucus and bicarbonate in the gastric mucosa, which leads to the accumulation of epidermal growth factor in the defect area and ulcer scarring.
In the process of neutralization, no carbon dioxide is formed, no flatulence occurs and, as a consequence, secondary hypersecretion.

Secrepat Forte Indication
For the symptomatic treatment of pain and heartburn in diseases of the gastrointestinal tract, such as peptic ulcer of the stomach, duodenum, gastroesophageal reflux disease, dyspepsia, acute and chronic gastritis with increased or normal secretion. Irritation of the gastric mucosa caused by smoking or dietary disorders (alcohol, coffee, sweets, flour products, etc.). As a prophylactic for long-term use of nonsteroidal anti-inflammatory drugs, glucocorticoids and other ulcerogenic drugs.

Hypersensitivity to the components of the drug; severe renal insufficiency (creatinine clearance below 30 ml / min); nephrolithiasis caused by the deposition of stones containing calcium; Alzheimer’s disease; hypophosphatemia; habitual constipation, chronic diarrhea, severe abdominal pain of unspecified origin; hypercalcemia and / or conditions leading to hypercalcemia; the patient’s age is up to 10 years.

Use during pregnancy or breastfeeding
During pregnancy, the drug can be used as prescribed and under the supervision of a physician if the expected benefit to the pregnant woman outweighs the potential risk to the fetus. It should take into account the content of aluminum and magnesium ions that can affect the transit in the gastrointestinal tract:

  • magnesium salts can cause diarrhea;
  • Aluminum salts can cause constipation and worsen the course of constipation, which is often observed during pregnancy.

The presence of calcium in high doses, used for a long time, increases the risk of hypercalcemia with calcification of various organs, including the kidneys.
Prolonged use and overdose of this drug should be avoided.
Pregnant women should avoid constant consumption of milk (1 liter contains up to 1.2 g of elemental calcium), as well as dairy products to prevent excess calcium, which can lead to the so-called milk-alkaline syndrome (Burnett’s syndrome), which is a rare but severe disease that requires medical attention.
If it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued for the entire period of drug use.

Method of application and dosage
The drug is used orally. The tablets are slowly absorbed or chewed. Adults are prescribed 1-2 tablets 4-6 times a day, the last time – just before bedtime. The drug is recommended to be taken 1-1.5 hours after a meal. The course of treatment is 3-4 weeks. For heartburn and stomach pain, the drug is taken in the same dose, but regardless of food intake (if necessary). For prophylactic purposes, to protect the mucous membrane from the irritating effect of drugs, take 1-2 tablets 2 hours before taking other drugs. Children aged 10 to 18 years are prescribed half the adult dose. The maximum daily dose for adults is 12 tablets.

If indicated, the drug is used in children over 10 years of age.

The drug in high doses, as well as with long-term use (more than 4 weeks) can cause nausea, vomiting, constipation, diarrhea, loss of appetite. Renal failure may also occur, especially in patients with impaired renal function, hypercalcemia, alkalosis, electrolyte disturbances (decreased phosphate and increased serum magnesium and aluminum), which are most likely in chronic renal failure, muscle weakness. Cases of acute overdose and symptoms of acute toxicity in humans were not observed. If the above symptoms occur, the drug should be discontinued and gastric lavage.

Side effects
The drug is usually well tolerated by patients. The Secret forte balances the possible astringent properties of aluminum and calcium with the laxative properties of magnesium. However, side effects can occur:

  • Immune system disorders: Hypersensitivity reactions including rash, pruritus, urticaria, angioneurotic edema and anaphylaxis.
  • Metabolic disorders. In patients, especially with renal impairment, long-term use of high doses may lead to hypermagnesemia (with the use of antacids containing magnesium) or hypercalcemia and alkalosis.
  • Hypercalciuria, hyperaluminaemia may also be observed.
  • From the gastrointestinal tract. There may be nausea, vomiting, stomach discomfort, diarrhea, constipation, discoloration of fecal masses.
  • From the musculoskeletal system and connective tissue. Muscle weakness may occur and osteomalacia with prolonged use.

Expiration date
5 years.
Do not use after the expiry date stated on the package.

Storage conditions Secrepat Forte
Store at a temperature not exceeding 25 ° C. Keep out of reach of children.