Septefril-Darnitsa (decamethoxine) tablets 0.2 mg. №10


Manufacturer: Ukraine

Local treatment as part of complex therapy of diseases of the oral cavity, pharynx, larynx (gingivitis, periodontitis, stomatitis, candidiasis of the oral mucosa, pharyngitis, laryngitis, tonsillitis, the initial stage of angina); sanitation of the oral cavity , pharynx, nasopharynx in carriers of pathogenic Staphylococcus, diphtheria Bacillus, Candida;


Septefril-Darnitsa (decamethoxine) tablets 0.2 mg. №10


active ingredient: decamethoxine;

1 tablet contains decamethoxin 0.2 mg;

excipients: crystalline sugar, calcium stearate.

Dosage form


Basic physical and chemical properties: tablets of white or almost white color, flat-cylindrical shape, with a risk and a chamfer.

Pharmacological group

Drugs used in diseases of the throat. Various antiseptics.
ATX code R02A A20.

Pharmacological properties

This drug belongs to the group of aseptic and disinfectants used for throat diseases.
Decamethoxin, which is the active ingredient of this drug, has a wide spectrum of antimicrobial action. It is active against gram-positive and gram-negative microorganisms.


The drug Septefril-Darnitsa is used for treatment in the complex therapy of diseases of the oral cavity, pharynx, larynx – pharyngitis, laryngitis, tonsillitis, gingivitis, periodontitis, stomatitis, candidiasis of the oral mucosa, at the initial stage of angina.
It is used to sanitize the oral cavity, pharynx, nasopharynx in carriers of pathogenic staphylococcus, diphtheria bacillus, candida.
Also prescribed to prevent complications after surgical interventions in the oral cavity, pharynx, larynx.
The drug has a bactericidal effect on staphylococci, streptococci, diphtheria bacillus, Pseudomonas aeruginosa, capsular bacteria and fungicidal action on yeast, yeast-like fungi, aspergillus, pathogens of epidermophytosis, trichophytosis, microsporia, erythrasma, mold fungi. It has an antiprotozial effect on Trichomonas and Giardia.
Decamethoxin also has the ability to increase the sensitivity of bacteria to antibiotics.
Bacteriostatic (fungistatic) concentrations of the drug are close to its fungicidal (bactericidal) concentrations.


This drug Septefril-Darnitsa is prohibited to use if the patient’s body reacts with manifestations of allergy when taking the main active ingredient – decamethoxin or ethanol, which is part of it.
Do not allow the drug to get on the mucous membranes of the eyes. In case of accidental contact, wash off the drug with plenty of running water.
Decamethoxin is a cationic surfactant. For this reason, it is incompatible with soap or other anionic substances (sodium lauryl sulfate, saponins), therefore, the soap should be thoroughly washed off before applying the drug to the skin.
You should pay attention to the fact that decamethoxin, which is part of the drug, has the property of increasing the antibiotic resistance (resistance) of microorganisms to antibiotics.
The use in pediatrics has not been studied.

Application during pregnancy and lactation

There is no data on the complete safety of use in pregnant women, since clinical trials are not carried out on this group of patients.

Method of administration and dosage

After rinsing the oral cavity, the Septefril-Darnitsa tablet is placed on the cheek and kept in the mouth, until completely dissolved.
For adults, this drug is prescribed 1 tablet 4-6 times a day.
The duration of treatment is no more than 7 days.
Take treatment with this drug after eating. And after taking this drug, you should refrain from food and drinks for 1 hour.


Overdose cases have not been reported at the moment and are not described in the medical literature. The reason may be that this drug has no systemic absorption, since it does not enter the systemic circulation when used externally.
In case of accidental swallowing, you should rinse the stomach, induce vomiting, take sorbents, and carry out symptomatic treatment.
The specific antidote is unknown.

Side effects

Usually the use of this drug is well tolerated by patients.
In rare cases, people with hypersensitivity to the drug may experience rashes on its surface, itching, which, however, quickly disappear after the end of treatment.