Serdolekt (sertindole) coated tablets 4 mg. №30


Schizophrenia. In accordance with the clause regarding cardiovascular safety, sertindol should be prescribed only to those patients whose treatment with at least one of the other antipsychotic agents was accompanied by reactions of intolerance to the drug. Sertindol should not be used in emergency situations to quickly relieve symptoms of exacerbation in patients.



Composition and form of release
The active ingredient in Serdolect is sertindole.
Available in the form of tablets of 4 mg (marked on the tablet “S4”).
Serdolect is a medicine designed to treat psychotic disorders.
It is mainly used to treat schizophrenia. It is not prescribed in emergency situations for the elimination of acute mental disorders.
Serdolekt is contraindicated for allergies to components, low levels of potassium and / or magnesium in the blood, severe cardiovascular diseases, an increase in the size of the heart muscle (myocardial hypertrophy), heart rhythm disturbances (arrhythmia, bradycardia, long QT syndrome), liver dysfunction.
Do not prescribe Serdolect together with drugs that lengthen the QT interval (antiarrhythmics, some antipsychotics, antibiotics, antiallergic drugs, etc.), drugs that inhibit the liver enzyme cytochrome P450 3A (antifungal agents, antibiotics-macrolides, HIV proteinase inhibitors, calcium channel blockers and etc.).
The safety of Serdolect for children has not been established.
Application during pregnancy and lactation
Does not apply during these periods.
Method of administration and dosage
Serdolect is prescribed internally. The tablet is taken regardless of food.
All patients begin treatment with Serdolect with a dose of 4 mg x 1 time per day. Then the daily dose is increased by 4 mg every 4–5 days until the desired medicinal effect is achieved (the optimal dose is 12–20 mg / day). The maximum dose that can be taken per day is 24 mg. The maximum dose is used in exceptional cases, since there is a risk of a decrease in the electrical conductivity of the heart (lengthening of the QT interval) with increasing doses.
When prescribing Serdolect, older people need a preliminary examination of the cardiovascular system. The dose of the drug in this case is chosen lower and increased slowly.
Lower doses should also be used in patients with moderate liver failure (in severe cases, the drug is prohibited).
When the dose is increased, it is necessary to conduct an ECG study.
Overdose signs: slurred speech, drowsiness, drop in blood pressure, temporary increase in the QT interval on the ECG. Perhaps the development of attacks of rapid and strong heartbeat – ventricular tachycardia (“torsade de pointes”).
Overdose treatment: immediate discontinuation of the drug, measures to maintain a sufficient level of oxygen in the blood, ensuring airway patency, immediate ECG examination and monitoring of the heart. If necessary, gastric lavage is performed, sorbents (activated carbon), laxatives are prescribed.
There is no specific antidote. The drug Serdolect cannot be withdrawn by dialysis.
Side effects
Runny nose, nasal breathing difficulties, fainting, decreased semen volume, dizziness, decreased pressure, dry mouth, weight gain, swelling, shortness of breath, creeping sensations on the skin, ECG changes (lengthening of the QT interval), changes in blood tests and urine (leukocyturia, hematuria, hyperglycemia), convulsions, movement disorders, bouts of rapid heartbeat.
Storage conditions and periods
Store Serdolect in its original packaging at temperatures up to 25 ° C. Serdolect’s shelf life is 5 years.