Seroquel XR is indicated for the treatment of schizophrenia, including the prevention of relapse in patients with stable schizophrenia who have received supportive therapy with Seroquel XR. Bipolar disorder, in particular: for the treatment of moderate and severe manic episodes in bipolar disorder; for the treatment of severe depressive episodes in bipolar disorder; for the prevention of relapse in patients with bipolar disorder, in patients with manic or depressive episodes in whom Seroquel XR treatment is effective. As adjunctive therapy in severe depressive episodes in patients with severe depressive disorder (TDR) who have a suboptimal response to antidepressant monotherapy. Prior to initiation of therapy, the safety profile of Seroquel XR should be carefully considered by the physician.
Composition and form of release
Active ingredient: quetiapine (200 mg).
Seroquel XR is produced in the form of extended-release tablets.
It is an antipsychotic agent. The active substance interacts with various types of neurotransmitter receptors, since it has a greater affinity for serotonin receptors than dopamine receptors in the brain, as well as a high affinity for α1-adreno-, histamine receptors, but less affinity for α2-adrenergic receptors. It has no affinity for benzodiazepine and M-cholinergic receptors. Possesses antipsychotic activity.
Seroquel XR is used:
- with schizophrenia;
- for manic episodes associated with bipolar disorder.
Seroquel XR does not apply:
- if you are allergic to quetiapine;
- with intolerance to excipients;
- with the simultaneous use of inhibitors of cytochrome P450 ZA4 (azole antifungal agents, inhibitors of HIV protease, erythromycin, nefazodone, clarithromycin).
Application during pregnancy and lactation
Safety and efficacy have not been investigated, therefore quetiapine XR can only be prescribed in cases where the need for treatment for the mother outweighs the risk to the fetus.
Withdrawal symptoms have been reported in newborns whose mothers were treated with quetiapine during pregnancy.
The excretion of quetiapine in breast milk has not been investigated, therefore, it is necessary to stop feeding during the treatment period.
Method of administration and dosage
Seroquel XR tablets are taken orally once a day at least one hour before a meal.
The doctor prescribes the dosage and duration of treatment individually.
The standard dose for schizophrenia is 50 mg on the 1st day, 100 mg on the 2nd day, 200 mg on the 3rd day, 300 mg on the 4th day. Then the dose is increased until the desired effect is achieved (usually within the range of 300-450 mg / day), maximum – 750 mg.
The standard dose in the course of treatment of manic episodes in bipolar disorder is 100 mg on the 1st day, 200 mg on the 2nd day, 300 mg on the 3rd day, 400 mg on the 4th day. In the future, the dose is increased (no more than 200 mg per day) to 800 mg, starting from the 6th day. Depending on the clinical efficacy and tolerability of the drug, the dose may be 200–800 mg / day, with a maximum of 800 mg.
Symptoms: lengthening of the Q – T interval, drowsiness, sedation, tachycardia, arterial hypotension.
In case of severe overdose, the possibility of using multidirectional measures, intensive care, incl. restoration / maintenance of airway patency, adequate oxygenation, lung ventilation, hemodynamic support.
- Hematological disorders: eosinophilia, neutropenia, thrombocytopenia.
- Immune disorders: hypersensitivity, incl. anaphylactic reaction.
- Mental disorders: nightmares, abnormal dreams, suicidal thoughts / behavior.
- Neurological disorders: dysarthria, seizures, headache, extrapyramidal disorders, loss of consciousness, restless legs syndrome, epilepsy, tardive dyskinesia.
- Cardiac disorders: prolongation of the Q – T interval on the electrocardiogram.
- Vascular disorders: venous thromboembolism.
- Ophthalmic disorders: blurred vision.
- Respiratory disorders: shortness of breath, rhinitis.
- Digestive disorders: dysphagia, vomiting, jaundice, hepatitis.
- Dermatological disorders: Quincke’s edema, Stevens-Johnson syndrome.
- Musculoskeletal disorders: rhabdomyolysis.
- Endocrine disorders: hyperprolactinemia, decreased secretion of vasopressin.
- Metabolic disorders: hyponatremia, hyperglycemia.
- Genitourinary disorders: priapism, galactorrhea, sexual dysfunction, breast swelling, dysmenorrhea.
- General: withdrawal symptoms, weight gain, increased appetite, irritability.
- Laboratory changes: increased levels of AlAT, AsAT, increased levels of γ-HT, TG, total cholesterol, decreased hemoglobin, CPK levels.
Storage conditions and periods
Store Seroquel XR in its original manufacturing container. Optimal temperature conditions: up to +30 degrees. It is good for three years after production (see the date on the packaging).