Servonex (donepezil) coated tablets 10 mg. №28


Symptomatic treatment of dementia of Alzheimer’s type of mild and moderate severity.

Category: Manufacturer: India


Composition and form of release
The main active ingredient of the drug is donepezil in the form of donepezil hydrochloride.
Excipients are: lactose monohydrate, microcrystalline cellulose, hydroxypropyl cellulose, corn starch, magnesium stearate.
It is produced in tablet form, in a dosage of 10 mg of the main active ingredient donepezil.
Pharmacological properties
This drug belongs to a group of drugs used to treat dementia, cholinesterase inhibitors.
The main active ingredient of the drug – donepezil – is a selective and reversible acetylcholinesterase inhibitor.
It has the property of inhibiting cholinesterase in the brain, and is also capable of blocking the breakdown of acetylcholine. The latter produces the transmission of nerve impulses of excitation in the central nervous system.
The effectiveness of donepezil in inhibiting acetylcholinesterase is 1,000 times higher than butyrylcholinesterase, which is contained in structures that are located outside the central nervous system.
This medication is intended for the treatment of symptoms of dementia (senile dementia) in patients with mild to moderate Alzheimer’s disease.
Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
It is contraindicated for use in case of gastric ulcer and duodenal ulcer, bronchial asthma.
Has an effect on drugs that have anticholinergic activity. With simultaneous use, it can enhance the activity of succinylcholine and other muscle relaxants or antagonists of cholinergic receptors and beta-blockers that affect cardiac conduction.
Atypical changes in blood pressure and heart rate while taking other cholinomimetics and quaternary anticholinergic drugs.
It is not used in pediatrics.
Application during pregnancy and lactation
Treatment of pregnant women is undesirable, since there is no guarantee of complete safety of its use for both the woman and the fetus.
During treatment, lactation (breastfeeding) should be suspended.
Method of administration and dosage
Servonex is taken in an initial dose of 10 mg, once a day, before going to bed.
This initial dosage is applied for one month.
After this period of time, the dosage of the drug can be doubled. The drug is also continued to be taken once a day, which is also the maximum allowable dose.
It is recommended to regularly evaluate the effect of the therapeutic dose. If there are no changes in the patient’s condition, then the drug should be discontinued and a different tactic of drug treatment should be chosen, depending on the individual reaction of the body, which cannot be predicted.
There is no data to suggest that dosage adjustment is required in patients with hepatic or renal impairment.
An overdose of this drug can cause a cholinergic crisis, the symptoms of which are:

  • severe nausea, vomiting, salivation;
  • excessive sweating;
  • bradycardia, arterial hypotension;
  • respiratory depression, collapse, convulsions;
  • muscle weakness, up to the defeat of the respiratory muscles, which can be fatal.

It is recommended to carry out symptomatic therapy, the use of tertiary anticholinergics, in particular atropine.
The effectiveness of hemodialysis has not been confirmed.
Side effects
This drug is usually well tolerated and rarely causes side effects. In particular, there may be:

  • nausea, diarrhea, vomiting;
  • anorexia;
  • hallucinations, agitation, anxiety;
  • rashes, itching;
  • muscle cramps;
  • urinary incontinence;
  • increased fatigue, pain;
  • increased injury rate.

If you experience any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.
Storage conditions and periods
The shelf life of the drug is no more than 2 years from the production date indicated on the package.
This medicinal product should be stored in a dry place out of the reach of children, at a temperature not exceeding 25 ° C.