Sirdalud (tizanidin) tablets 4 mg. №30


Tizanidine is a muscle relaxant of central skeletal muscle. The main site of action is the spinal cord. The drug reduces resistance to passive movements, suppresses spasm and cramps and improves the strength of active muscle contractions. Tizanidine is quickly and completely absorbed into the digestive tract, into the bloodstream. Excretion mainly occurs by the kidneys. Painful muscle spasm. Spasticity due to multiple sclerosis, damage to the brain and spinal cord.

Category: Manufacturer: Turkey


Composition and form of release
The active ingredient is tizanidine hydrochloride – 4 mg. Contains auxiliary components. Produced in tablet form.
It is used when it is necessary to relieve spasms of the skeletal muscles caused by radiculitis, cervical syndrome, neurological pathologies such as multiple sclerosis, degenerative diseases of the spinal cord, cerebral palsy, chronic myelopathy, circulatory disorders of the brain, etc.
It is also prescribed during the rehabilitation period after operations, in particular, after surgical interventions regarding the displacement of the intervertebral disc, accompanied by rupture of the annulus fibrosus, deforming osteoarthritis of the hip joint. It also effectively relieves pain attacks due to muscle spasms, spasticity due to multiple sclerosis, brain and spinal cord lesions.
Tizanidine, which is a centrally acting muscle relaxant, is able to affect the skeletal muscles, reducing muscle tone. Due to this property, the polysynaptic way suppresses the transmission of excitation, which occurs at the stage of intermediate neurons of the spinal cord.
Has some anesthetic effect. It is able to reduce clonic spasms, convulsions, increases the strength of voluntary contractions of the skeletal muscles.
Not applicable in case of hypersensitivity to tizanidine, or to additional substances. The use of this drug is also contraindicated in severe liver dysfunction; it should not be used in combination with fluvoxamine or ciporfloxacin. Prescribed with caution in elderly patients, due to the likelihood of poor kidney function.
Application during pregnancy and lactation
Clinical research has not been carried out on pregnant women, so there is no complete confidence in the complete safety of its action on a woman and her fetus, although experiments on animals have not revealed any negative consequences. The drug penetrates into breast milk, therefore, lactation should be canceled while taking it.
Method of administration and dosage
If it is necessary to relieve muscle spasm caused by neuralgia, the initial dose is 6 milligrams per day, which is taken in three doses throughout the day. After 3-7 days, it is permissible to increase the dose by 2-4 milligrams. The optimal dosage is from 12 to 24 mg, the maximum is 36 milligrams per day.
For painful muscle spasm, take 2 to 4 mg per day, you can take the same dose at night (with severe spasm).
Overdose symptoms were noted when taking more than 400 mg of the drug. There were signs of intoxication, a drop in pressure, manifestations of drowsiness, loss of consciousness up to a coma.
Symptomatic treatment, gastric lavage, and drinking plenty of fluids are recommended.
Side effects
Most often, side effects from the gastrointestinal tract (nausea, diarrhea) are observed, manifestations of muscle weakness, drowsiness may occur. Symptoms may be more severe at higher dosages.
Storage conditions and periods
Store up to 4 years at temperatures up to 25 ° С