To reduce the toxicity and neutralize the effects of folic acid antagonists (such as methotrexate) during cytotoxic therapy and in overdose in adults and children. When carrying out cytotoxic therapy, this procedure is known as “rescue therapy” by folinate. In combination with 5-fluorouracil for cytotoxic therapy. Pay attention. Continuously high serological levels of methotrexate can also be expected with low dose methotrexate therapy, in particular pleural effusions, ascites, renal insufficiency and insufficient fluid intake during methotrexate therapy.