Solu-medrol (methylprednisolone) 1000 mg. 15.6 ml. with solvent


The use of glucocorticoids should be considered as a symptomatic treatment only, with the exception of individual endocrine disorders when used as a replacement therapy. Corticosteroids for systemic use.



Composition and form of release
The main active ingredient is methylprednisolone.
Excipients: sodium dihydrogen phosphate (monohydrate), sodium hydrogen phosphate anhydrous.
Produced in the form of a powder for the preparation of an injection solution, in vials at a dosage of 1000 mg. It comes with a solvent for the preparation of injections.
Pharmacological properties
This drug belongs to the group of antimicrobial and antiseptic substances based on corticosteroid components, intended for systemic use.
Methylprednisolone is a synthetic glucorticosteroid used to reduce inflammation by inhibiting the secretion and release of inflammatory mediators. In addition to anti-inflammatory, it also has antiallergic and immunosuppressive effects.
Promotes inhibition of the accumulation of cells (leukocytes, macrophages, etc.) in the inflamed area. Helps reduce capillary permeability.
It has an immunosuppressive effect, affects the balance of electrolytes, contributing to the enhancement of the reabsorption of water and sodium, increasing the release of sodium molecules and hydrogen ions.
Increases protein catabolism, glucose and lipid acid levels in the blood, affects the metabolism of amino acids.
Its use also reduces the likelihood of scar tissue formation as it reduces collagen production.
This drug is used when a glucocorticoid is needed. In particular, during therapy:

  • acute allergic reactions;
  • bronchial asthma and status asthma;
  • shock, incl. resistant to other therapy;
  • myocardial infarction;
  • acute adrenal insufficiency;
  • cirrhosis of the liver;
  • acute hepatitis;
  • acute hepatic renal failure;
  • poisoning with cauterizing liquids (in order to reduce inflammation and prevent cicatricial narrowing).

Also used for the prevention or treatment of thyrotoxic reaction and thyrotoxic crisis, some oncological, endocrine, dermatological, hematological and neurological diseases, eye diseases, pericarditis, and to prevent transplant rejection during organ transplantation. Effective for intra-articular administration in the treatment of arthrosis, arthritis, and other joint diseases.
You should not use the specified drug if the patient has had a previous hypersensitivity (allergy) with respect to one of the components that are part of the drug – both main and auxiliary.
Contraindicated in:

  • stomach ulcer and 12 duodenal ulcer;
  • Cushing’s syndrome, hypothyroidism, thyrotoxicosis, diabetes mellitus;
  • osteoporosis, myasthenia gravis;
  • chickenpox;
  • diabetes mellitus;
  • predisposition to thromboembolism, myocardial infarction;
  • renal failure;
  • severe arterial hypertension;
  • simple and herpes zoster;
  • during the vaccination period.

Application during pregnancy and lactation
Treatment of pregnant women in the first trimester is carried out with great care, only according to indications, since there is a risk of impaired fetal growth or complications from the adrenal glands.
In the II and III trimester, as well as during breastfeeding, treatment with this drug is allowed, since it enters the bloodstream in doses that are safe for the mother and child.
Method of administration and dosage
Injection solution is administered intramuscularly, intravenously, or as an infusion (dropper).
The dosage and duration of treatment is determined by the attending physician. The minimum dosage is from 0.5 mg per 1 kg of the patient’s weight mg per day, depending on the type and severity of the disease. The average dosage is 30 mg per 1 kg of patient weight.
In particular, in case of shock, a dosage is administered at the rate of 30 mg per 1 kg of body weight (in children, from 1 to 3 mg per 1 kg of the patient’s body weight). The introduction is slow, within 30-60 minutes. The course of treatment should not last longer than 72 hours due to the risks of systemic side effects.
Sodium chloride or glucose is used as a solvent.
It should be noted that it is forbidden to suddenly stop the course of treatment, especially if the course was long. In this case, the treatment is discontinued with a gradual decrease in the frequency of administration and dosage size.
An overdose of this drug can cause increased side effects and edema.
In general, symptomatic treatment is recommended.

Side effects
The drug is usually well tolerated. Side effects can occur only with prolonged use of the drug.
In this case, you may observe:

  • convulsions, increased intracranial pressure;
  • Cushing’s syndrome, growth suppression in children, menstrual irregularities, hyperglycemia, glucosuria, decreased carbohydrate tolerance;
  • cataract, glaucoma, exophthalmos;
  • leukocytosis;
  • thrombosis;
  • anaphylactic reactions, hypersensitivity reactions, arteritis obliterans, weight gain due to increased appetite, fainting;
  • cataract, glaucoma;
  • bronchospasm;
  • relapse of tuberculosis.

Storage conditions and periods
This medicinal product is able to retain its medicinal properties for 2 years (for dosages of 40 and 125 mg) and for 5 years (for dosages of 500 and 1,000 mg), from the production date indicated on the package.
Storage is carried out in a dry place, away from sunlight.
Storage temperature should not exceed 25 ° C.