Somazina (citicoline) solution for injections 1000 mg/4 ml. ampoules №10


Stroke, acute phase of cerebral circulation disorders and treatment of complications and consequences of cerebral circulation disorders. Traumatic brain injury and its neurological consequences. Cognitive and behavioral disorders due to chronic vascular and degenerative cerebral disorders.

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active substance: citicoline (as sodium salt);
1 ampoule (4 ml) of solution contains citicoline (in the form of sodium salt) 500 mg or 1000 mg;
Excipients: concentrated hydrochloric acid or sodium hydroxide to adjust the pH, water for injections.
Dosage form
Solution for injection.
Pharmacological properties
Citicoline stimulates the biosynthesis of structural phospholipids of neuronal membranes, which is confirmed by magnetic resonance spectroscopy. Citicoline improves the functioning of membrane mechanisms such as ion pumps and receptors, without the regulation of which the normal conduction of nerve impulses is impossible. Due to the stabilizing effect on the membrane of neurons, citicoline has anti-edematous properties that promote the reabsorption of cerebral edema.
Clinical studies have shown that citicoline inhibits the activation of certain phospholipases (A1, A2, C and D), reducing the formation of free radicals, preventing the destruction of membrane systems and preserving antioxidant defense systems such as glutathione.
Citicoline preserves the neural energy reserve, inhibits apoptosis, which improves cholinergic transmission.
It has been experimentally proven that citicoline also has a prophylactic neuroprotective effect in focal cerebral ischemia.
Clinical studies have shown that citicoline significantly increases the rate of functional recovery in patients with acute cerebral circulatory disorders, which coincides with a slowdown in the growth of ischemic brain damage according to neuroimaging. In patients with traumatic brain injury, citicoline accelerates recovery and reduces the duration and intensity of post-traumatic stress disorder.
Citicoline improves attention and consciousness, helps reduce the manifestations of amnesia, cognitive and other neurological disorders associated with cerebral ischemia.
Stroke, acute phase of cerebrovascular disorders and treatment of complications and consequences of cerebrovascular disorders.
Traumatic brain injury and its neurological consequences.
Cognitive and behavioral disorders due to chronic vascular and degenerative cerebral disorders.
Hypersensitivity to any component of the drug.
Increased tone of the parasympathetic nervous system.
Method of application and dosage
The drug is used for intravenous or intramuscular administration, intravenously administered in the form of a slow intravenous injection (for 3-5 minutes depending on the prescribed dose) or intravenously (40-60 drops per minute).
The recommended dose for adults is 500-2000 mg / day, depending on the severity of the patient’s condition.
The maximum daily dose is 2000 mg.
In acute and urgent conditions, the maximum therapeutic effect is achieved when prescribing the drug in the first 24 hours.
The duration of treatment depends on the course of the disease and is determined by the doctor.
No dose adjustment is required for elderly patients.
The drug is compatible with all intravenous isotonic solutions, as well as with hypertonic glucose solutions.
This solution is intended for single use. The solution should be injected immediately after opening the ampoule. Any unused solution should be discarded.
If necessary, treatment is continued with the drug in the form of a solution for oral administration.
Experience in children is limited, so the drug is prescribed only when the expected benefits outweigh any potential risks.
Cases of overdose are not described.
Side effects:

  • From the central and peripheral nervous systems: severe headache, vertigo, hallucinations.
  • From the cardiovascular system: hypertension, hypotension, tachycardia.
  • From the respiratory system: shortness of breath.
  • From the digestive tract: nausea, vomiting, diarrhea.
  • From the immune system: allergic reactions, including: rash, redness, exanthema, urticaria, purpura, pruritus, angioneurotic edema, anaphylactic shock.
  • General reactions: chills, changes in the injection site.

Expiration date
3 years.
Storage conditions
Store in the original package at a temperature not exceeding 30 ° C.
Keep out of reach of children.