Spark (mebeverin hydrochloride) hard capsules with prolonged release 200 mg. №30


Adults and children over 10 years: symptomatic treatment of abdominal pain and cramping, intestinal disorders and discomfort in the intestine with irritable bowel syndrome; treatment of gastrointestinal spasms of secondary origin caused by organic diseases.



Composition and form of release
Active ingredients: mebeverine hydrochloride (200 mg).
Spark is available in the form of extended-release capsules.
Pharmacological properties
It is a myotropic antispasmodic agent. Has a direct effect on the smooth muscles of the gastrointestinal tract, without affecting the normal intestinal motility. Reduces the permeability of ion channels, blocks the reuptake of norepinephrine, has a local anesthetic effect, alters the absorption of water. It normalizes intestinal motility without causing relaxation of smooth muscle fibers of the gastrointestinal tract.

  • for the symptomatic treatment of spasms, pain, discomfort in the intestinal region associated with irritable bowel syndrome;
  • for the symptomatic treatment of spasms of the gastrointestinal tract.


  • with an allergy to an active ingredient;
  • with intolerance to auxiliary components;
  • under the age of 18;
  • during pregnancy, breastfeeding.

Application during pregnancy and lactation
There is not enough data on the use of the drug during pregnancy, so the use is not recommended.
There is insufficient information on the excretion of the active substance (mebeverine) or its metabolites in mother’s milk. During breastfeeding, the drug is not used. If necessary, taking trimebutine breastfeeding is stopped.
There are not enough clinical data on the effect of the active substance (mebeverine) on female and male fertility, however, animal studies have not demonstrated a harmful effect on reproductive function.
Method of administration and dosage
Spark is applied orally 20 minutes before meals. The capsule should not be chewed as the capsule shell provides a sustained release of the drug. Capsules must be taken with a sufficient volume of water (at least one hundred milliliters).
The standard dose is 200 mg twice a day (morning and evening).
The duration of admission is not limited.
If you miss one or more doses, the drug must be continued with the next dose. Missed doses do not need to be taken in addition to your usual dose.
Dosage studies in patients with renal / hepatic insufficiency, elderly patients have not been conducted. The available data did not identify risk factors in the treatment of these categories of patients, so a change in the dosage regimen is not required.
Symptoms: increased excitability of the central nervous system, cardiovascular disorders.
In the described cases of overdose, the symptoms of intoxication were not observed or they were mild and quickly disappeared. Gastric lavage is advisable within 1 hour from the moment of taking the drug.
Treatment: symptomatic treatment is recommended.
If the dose is exceeded, signs of an overdose are detected, it is required to stop taking this drug, consult with your doctor.
Side effects
Allergic reactions: angioedema, urticaria, exanthema.
Dermatological disorders: itching, dermatitis.
Storage conditions and periods
Store Spark in its original packaging at temperatures up to + 25 ° C. The shelf life is two years. The use of the drug after the expiration date indicated on the package is prohibited.
Parents need to ensure the safety of their children by excluding their access to medicine.