Stillen (wormwood leaf extract) coated tablets 60 mg. №30


Treatment of lesions of the gastric mucosa (erosion, hemorrhage, hyperemia, edema) in acute and chronic gastritis; gastritis caused by Helicobacter pylory infection (in the case of simultaneous administration of Helicobacter pylory eradication drugs). Prevention of gastritis caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs).


1 film-coated tablet contains:
active substance: 60 mg of wormwood leaf extract Artemisiae Argyi, soft (20: 1), containing 0.48 – 1.44 mg of eupatilin and 0.15–0.45 mg of geyseosidine, 95% ethanol extractant;
excipients: microcrystalline cellulose; lactose monohydrate; poloxamer; croscarmellose sodium; calcium silicate; talc; magnesium stearate;
Pharmacological properties
Stylene has a healing effect on the gastric mucosa in gastritis by enhancing the regenerative processes in the affected cells of the mucous membrane. The reparative properties of the drug are provided by flavonoids, which stimulate protein synthesis and improve local blood supply.
The anti-inflammatory activity of Stylene is realized through pronounced antioxidant properties, which prevent lipid peroxidation and block the formation of bioreactive forms of oxygen, inhibiting the release of leukotriene D4 caused by Helicobacter pylori in vitro, and reduce the activation of transcriptional N-transcriptional activation.
Stylene protects the gastric mucosa from the damaging effects of various ulcerogens, such as alcohol and nonsteroidal anti-inflammatory drugs (NSAIDs). Protection of the gastric mucosa from damage caused by alcohol is carried out by inhibiting the activity of xanthine oxidase and oxidative stress. Prevention of damage to the gastric mucosa with the use of NSAIDs is provided by increased release of endogenous prostaglandin E2 from peritoneal neutrophils and reduced production of prostaglandin F1ɑ. Stylene stimulates the secretion of mucus by the gastric epithelium, without affecting the basal secretion of gastric juice and the production of hydrochloric acid.
Treatment of lesions of the gastric mucosa (erosion, hemorrhage, redness, edema) in acute and chronic gastritis; gastritis caused by Helicobacter pylory infection (in case of concomitant use of drugs used to eradicate Helicobacter pylory).
Prevention of gastritis caused by non-steroidal anti-inflammatory drugs (NSAIDs).
Hypersensitivity to the components of the drug. Hereditary galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
Special security measures
Use with caution in patients with:

  • thrombosis (thrombosis of cerebral vessels, myocardial infarction, thrombophlebitis, etc.);
  • coagulopathy;
  • severe liver, kidney, heart, lung and blood disorders;
  • symptoms of drug allergy (rash, fever, itching, etc.) or with a history of drug allergy symptoms.

Interaction with other drugs and other types of interaction
There are no data on interaction with other drugs.
Features of application
If symptoms do not improve after 2 weeks of use, therapy should be reconsidered.
Use during pregnancy or breastfeeding
Contraindicated (increases uterine tone).
It is not known whether the drug gets into breast milk. Therefore, it should not be used by women who are breast-feeding.
Ability to influence the speed of reaction when driving a car or other machinery.
No studies on the effects on the ability to drive and use machines have been performed.
Method of application and dosage
Stylene is administered orally 20-30 minutes before meals 1 tablet 3 times a day.
The maximum single dose is 1 tablet. The maximum daily dose is 3 tablets. The duration of treatment is 2-4 weeks.
Due to the lack of experience in children, Stylene should not be prescribed to patients under 18 years of age.
No cases of overdose have been studied with the use of tablets.
Side effects:

  • From the gastrointestinal tract: sometimes observed nausea, anorexia, diarrhea, vomiting, heartburn and pain in the upper abdomen.
  • From the nervous system: sometimes there were dizziness and headache.
  • From the skin and subcutaneous tissue: sometimes there was a rash and itching.
  • From the hepatobiliary system: sometimes there was an increase in ALT.
  • There is a report of facial edema, although a causal relationship with the drug Stylene has not been established.

Expiration date
3 years.
Storage conditions
Store in the original package at a temperature not exceeding 25 ° C. Keep out of reach of children.