active substances: butamirate citrate, guaifenesin;
5 ml of syrup contain butamirate citrate 4 mg, guaifenesin 100 mg;
excipients: liquid maltitol; sorbic acid; citric acid, monohydrate; sodium citrate; propyl gallate; disodium edetate; potassium acesulfame; sodium cyclamate; hydroxyethylcellulose; caramel-iris flavoring; purified water.
Main physical and chemical properties: clear colorless or yellowish solution with a light aroma.
Combined drug that has antitussive, mucolytic and expectorant action. Butamirate dihydrogen citrate belongs to the non-opioid antitussives of peripheral action. It has a local anesthetic effect on nerve endings that transmit upward signals of irritation from the respiratory tract. Unlike opioid antitussives, it does not cause a central inhibitory effect, does not depress the respiratory center, does not cause dependence.
The antitussive effect of dihydrogen citrate butamirate is supplemented by the expectorant action of guaifenesin. Guaifenesin has secretolytic (by directly enhancing the secretion of bronchial glands and stimulating the elimination of acidic glycoproteins from acinar cells) and secretomotor properties (reduces the viscosity of sputum and facilitates the evacuation of mucus and its cough).
Dry irritable paroxysmal cough of various origins; the drug can be used to relieve cough in the pre- and postoperative period.
Hypersensitivity to the components of the drug, myasthenia gravis.
Method of application and dosage
This medicine is for use in children 6 months of age and older. The dosage should be selected depending on the patient’s body weight:
- up to 12 kg 1.25 ml 3-4 times a day;
- 12-20 kg 2.5 ml 3 times a day;
- 20-40 kg 2.5 ml 3-4 times a day;
- 40-70 kg 5 ml 3 times a day;
- 70-90 kg 5 ml 4 times a day;
- from 90 kg 7.5 ml 3-4 times a day.
The interval between receptions should make 4-6 hours.
The drug is recommended to take after a meal, drinking plenty of fluids (water, tea, fruit juice).
Do not take the drug for more than 7 days without consulting a doctor.
The drug should be used in children from 6 months of age according to the indications (doses and method of application are given in the section “Method of administration and doses”).
Overdose is dominated by signs of toxic effects of guaifenesin – drowsiness, muscle weakness, nausea, vomiting, diarrhea, dizziness, hypotension. X-ray negative urolithiasis is possible.
There is no specific antidote.
Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy aimed at maintaining the functions of the cardiovascular and respiratory systems, renal function and maintaining electrolyte balance.
If you follow the recommended dosage, patients tolerate the drug well. Side effects usually disappear after reducing the dose.
- From the metabolism: lack of appetite.
- From the nervous system: headache, drowsiness.
- From the respiratory system: shortness of breath.
- Hearing impairment and vestibular disorders: dizziness.
- From the gastrointestinal tract: discomfort in the digestive tract, nausea, stomach pain, vomiting, diarrhea. If you experience stomach discomfort or other unusual effects, you should stop using the drug and consult a doctor.
- From the skin and subcutaneous tissue: allergic reactions, including anaphylactic shock; angioneurotic edema, skin rash, itching, urticaria, exanthema.
- From the urinary system: urolithiasis.
After the first opening – 4 weeks.
Store in the original package at a temperature not exceeding 25 ° C out of reach of children.