Streptocid-Darnytsia (sulfanilamide) tablets 0.3 g. №10


Manufacturer: Ukraine

Infectious diseases caused by susceptible microorganisms: infectious diseases of the skin and mucous membranes (wounds, ulcers, bedsores), enterocolitis, pyelitis, cystitis.


Streptocid-Darnytsia (sulfanilamide) tablets 0.3 g. №10


active substance: sulfanilamide;

1 tablet contains sulfanilamide 300 mg;

Excipients: potato starch, povidone, colloidal anhydrous silica, stearic acid.

Dosage form


Main physical and chemical properties: white tablets, flat-cylindrical, with a dash and bevel.

Pharmacotherapeutic group

Antibacterial agents for systemic use. Short-acting sulfanilamides.
ATX code J01E B06.

Pharmacological properties

Streptocide, like other sulfonamides, disrupts the formation of growth factors in microorganisms – folic, dihydrofolic acids, other compounds containing paraaminobenzoic acid in their molecule. Due to the fact that its structure is close to the structure of streptocide, the latter as a competitive antagonist of this acid is included in the metabolic chain of microorganisms and disrupts metabolic processes, which leads to a bacteriostatic effect. The drug belongs to the short-acting sulfonamides. Streptocide has a bacteriostatic effect on streptococci, meningococci, pneumococci, gonococci, Escherichia coli, toxoplasmosis and malaria. In terms of effectiveness, it is much inferior to modern antibiotics. Currently, many strains of microorganisms, especially nosocomial, are resistant to streptocide.

Streptocide activity increases in an alkaline environment.

Streptocide-insensitive enterococci, Pseudomonas aeruginosa, anaerobes.


Infectious and inflammatory diseases caused by drug-sensitive microorganisms: infectious diseases of the skin and mucous membranes (wounds, ulcers, bedsores), enterocolitis, pyelitis, cystitis.


You can not prescribe Streptocid-Darnytsia tablets:

  • with allergies to sulfonamides, as well as intolerance to auxiliary components;
  • with inhibition of hematopoiesis in the bone marrow;
  • in the presence of severe toxic-allergic reactions to sulfonamides in the past;
  • with uncompensated heart failure;
  • with diseases of the hematopoietic system;
  • with anemia;
  • with leukopenia;
  • with Graves’ disease (toxic goiter);
  • with kidney / liver diseases (nephrosis, nephritis, liver failure, severe kidney failure, acute hepatitis);
  • with hyperthyroidism;
  • with a deficiency of glucose-6-phosphate dehydrogenase;
  • with azotemia;
  • with porphyria.

Streptocid should be prescribed with caution to patients with chronic heart failure, liver disease, impaired renal function, severe allergic diseases, bronchial asthma, blood diseases, as well as diabetes mellitus, since high doses have a hypoglycemic effect (can lower sugar levels in blood).
Since the drug is a bacteriostatic, and not a bactericidal agent, a full course of treatment is required to prevent the recurrence (repetition) of infection, the development of resistant forms of microorganisms.
Given the chemical similarity of the structures, sulfonamides cannot be used by people allergic to furosemide, thiazide diuretics, carbonic anhydrase inhibitors, sulfonylurea derivatives.

Application during pregnancy and lactation

This medicine is contraindicated during these periods. If necessary, treatment during breastfeeding, feeding is stopped.

Method of administration and dosage

Streptocid-Darnytsia tablets  take orally during or after a meal, drinking 150-200 ml of water. Single dose for adults and children over 12 years of age is 600 mg – 1.2 g, daily dose – 3-6 g. The daily dose is divided into 5 doses.

Children aged 3 to 6 years – 300 mg per 1 dose, from 6 to 12 years – 300-600 mg per 1 dose. The frequency of admission for children is 4-6 times a day.

The duration of treatment is determined individually and depends on the severity and course of the disease, the localization of the process, the effectiveness of therapy.

Higher doses for adults: single – 2 g, daily – 7 g.

The maximum daily dose for children – 900 mg – 2.4 g


The drug Streptocid-Darnytsia tablets is used for children over 3 years of age.


In case of an overdose, anorexia (lack of appetite), colicky pains, vomiting, headache, drowsiness, dizziness, fainting are possible. With prolonged use, fever, crystalluria, the appearance of blood in the urine (hematuria), cyanosis of the skin (cyanosis), heart palpitations (tachycardia), tingling sensations, “creeping” on the skin (paresthesia), loose stools (diarrhea), jaundice ( due to cholestasis, toxic hepatitis), renal failure with anuria, changes in the blood test (agranulocytosis, leukopenia).
Overdose treatment: immediately consult a doctor who will prescribe symptomatic treatment. Emergency care: gastric lavage, intake of enterosorbents, drinking plenty of fluids, forced diuresis. If necessary, hemodialysis is performed.

Side effects:

  • Co side of the blood, lymphatic system: thrombocytopenia, leukopenia, agranulocytosis, hypoprothrombinemia, aplastic anemia, eosinophilia, hemolytic anemia.
  • Co side of the cardiovascular system: myocarditis, tachycardia.
  • From the side of the nervous system: aseptic meningitis, ataxia, headache, intracranial hypotension, convulsions, drowsiness / insomnia, dizziness, fatigue, peripheral neuropathy, optic neuropathy, depression, visual impairment, depression, psychosis, paresthesia.
  • Co side of the respiratory system: fibrosing alveolitis, pulmonary infiltrates.
  • Co side of the digestive tract: dry mouth, thirst, dyspeptic symptoms, diarrhea, nausea, anorexia, pseudomembranous colitis, pancreatitis.
  • Co side of the digestive system: cholestatic hepatitis, increased activity of liver enzymes (ALAT, ASAT, alkaline phosphatase), hepatonecrosis (breakdown of liver tissue), jaundice, hepatomegaly (enlarged liver), cholestasis.
  • Co side of the urinary system: crystalluria (with an acidic reaction of urine), discoloration of urine (yellow-brown color), nephrotoxic reactions (tubular necrosis, interstitial nephritis, renal failure, shock kidney with anuria, hematuria).
  • Co side of the skin: hyperemia (redness), skin rashes (papular, erythematous-squamous), itching, allergic dermatitis, urticaria, photosensitivity, erythema nodosum, exfoliative dermatitis, cyanosis.
  • Allergic reactions: serum syndrome, Lyell’s, Stevens-Johnson’s syndromes, systemic lupus erythematosus, anaphylactic reactions, runny nose, Quincke’s edema.
  • General disorders: pain in the right hypochondrium, lower back, drug fever.
  • Others: periarteritis nodosa, shortness of breath, hypothyroidism, hypothyroidism, hypoglycemia.