Sufer (iron (i) hydroxide sucrose complex) solution for intravenous injections 20 mg/ml. 5 ml. №5


Iron deficiency in patients who cannot be prescribed oral iron preparations or if they are ineffective in the following cases: intolerance to oral iron preparations; the presence of inflammatory diseases of the gastrointestinal tract (eg, ulcerative colitis), which can be exacerbated during treatment with oral iron; iron-deficient conditions resistant to therapy in the case when the control of these conditions with oral iron preparations is insufficient.



Composition and form of release
Available as a solution (20 mg / ml).
Sufer active ingredient: iron (III) hydroxide-sucrose complex.
Pharmacological properties
Iron preparation for intravenous administration. It is used for quick clinical, hematological correction of a reduced hemoglobin index. Reduces the need for erythropoietin by 25% while using it.
Sufer is used for iron deficiency states:

  • with the ineffectiveness of treatment with oral dosage forms of iron (due to the syndrome of impaired absorption in the intestine, chronic enterocolitis, ulcerative colitis, after resection of the stomach or small intestine);
  • if you need to quickly replenish iron stores (for example, with severe post-hemorrhagic anemia, treatment with erythropoietin).

You cannot use Sufer:

  • with allergies to the components of the drug;
  • with anemia not associated with iron deficiency;
  • when the body is oversaturated with iron (hemochromatosis, hemosiderosis), violation of the process of its elimination.

Application during pregnancy and lactation
There have been no studies in pregnant women. Limited experience of use in such patients showed no undesirable effect on the normal course of pregnancy, fetal / child health. When prescribing, the risk / benefit ratio should be taken into account.
The use of Sufer is contraindicated in the first trimester.
The ingestion of unmetabolized iron sucrose in a woman’s milk is unlikely. Thus, the drug is not dangerous for a breastfed baby.
Method of administration and dosage
The solution is administered only intravenously – by long-term injection or drip. Also, the introduction is possible in the venous section of the dialysis system.
A test dose should be administered before starting treatment with full therapeutic doses. In this case, resuscitation funds should be available.
It is advisable to administer the solution by drip infusion in order to avoid the development of arterial hypotension, the danger of the drug getting into the perineous space.
Immediately before administration, the drug must be diluted in a 0.9% NaCl solution in a ratio of 1:20. The resulting solution is administered at a rate of 100 mg of iron for 15 minutes; 200 mg of iron – 30 minutes; 300 mg of iron – in 1.5 hours; 400 mg – in 2.5 hours; 500 mg of iron – in 3.5 hours.
The maximum allowable single dose is 7 mg of iron per 1 kg of weight.
The maximum tolerated dose in the form of infusion is prescribed no more than 1 time / week.
Intravenous jet injection is carried out at a rate of 1 ml per minute, but the maximum volume of the injected solution should not exceed 10 ml (200 mg of iron) per injection.
The solution can be injected directly into the venous area of ​​the hemodialysis system, following the rules for intravenous injection.
The dose is calculated individually, depending on the iron deficiency in the body.
An overdose can cause an acute oversaturation of the body with iron, which is manifested by the development of hemosiderosis (excessive deposition of hemosiderin pigment in tissues). In case of an overdose, symptomatic agents are used, as well as chelates (substances that bind iron).
Side effects
Possible: dizziness, loss of consciousness, palpitations, arterial hypotension, tachycardia, collapse, feeling of heat, edema, bronchospasm, hot flushes, shortness of breath, epigastric pain, changes in stool, loss of taste, nausea, rash, erythema, itching, pigmentation disorders, sweating, arthralgia, muscle pain, joint edema, paresthesia, headache, laryngeal edema, face, anaphylactoid (pseudo-allergic) reactions, chest pain, pain in the extremities, weakness, malaise, chills, feeling of heaviness in the chest, fever, pallor , pain and swelling at the injection site.
Storage conditions and periods
Store no more than 3 years in a dark place. Don’t freeze.