Sulcef (sulbactam/cefoperazone) powder for solution for injections 1g+1g. №1 vial

$39.60

The drug should be used to treat the following infections caused by susceptible strains of microorganisms: respiratory tract infections (upper and lower parts); urinary tract infections (upper and lower divisions); peritonitis, cholecystitis, cholangitis and other infections of the abdominal cavity; septicemia; meningitis; skin and soft tissue infections; infections of bones and joints; pelvic inflammatory diseases, endometritis, gonorrhea and other genital infections.

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Description

Composition and form of release
The main active ingredients are cefoperazone (in the form of cefoperazone sodium) and sulbactam (in the form of sodium sulbactam) in a 1: 1 ratio.
It is produced in the form of a combined powder for preparation of injections at a dosage of 2 grams (1000 mg cefoperazone / 1000 mg sulbactam) in 1 bottle.
Pharmacological properties
This drug is a two-component antibacterial drug for systemic use, which consists of two active ingredients: cefoperazone and sulbactam. The antibacterial component of the drug is cefoperazone, which is a third-generation cephalosporin.
It is active in relatively sensitive microorganisms, which are in the stage of active multiplication, due to the property of inhibiting the biosynthesis of the mucopeptide of the cell membrane.
Sulbactam, in turn, enhances the effect of cefoperazone.
Indications
This drug is used to treat diseases that are caused by pathogens sensitive to this combination of drugs (cefperazone with sulbactam), both in complex and in monotherapy. In particular, it is prescribed for the treatment of infections:

  • respiratory tract (including pneumonia, including hospital and aspiration, bronchitis, endobronchitis, empyema or lung abscess);
  • urinary tract (pyelonephritis, kidney abscess, cystitis, apostematous nephritis);
  • skin, soft tissues (abscesses, phlegmons, purulent-inflammatory diseases of pararectal tissue, gangrene of the extremities);
  • bones and joints (bacterial arthritis, osteomyelitis);
  • genitourinary system in men (prostatitis, orchitis, epididymitis.
  • small pelvis (endometritis, gonorrhea);
  • abdominal cavity – peritonitis, cholecystitis, cholangitis.

It is also prescribed for the treatment of septicemia, meningitis.
Cefoperazone is a third generation cephalosporin. It is active in relatively sensitive microorganisms, which are in the stage of active multiplication, due to the property of inhibiting the biosynthesis of the mucopeptide of the cell membrane.
Sulbactam has no real antibacterial activity, except for the action of 2 microorganisms (Neisseriaceae and Acinetobacter). However, biochemical studies have shown that due to the various mechanisms of action of this substance, it has the property of enhancing the action of cefoperazone against a wide range of clinically significant microorganisms.
Contraindications
Do not use for allergic reactions to drugs of the cephalosporin group, including cefoperazone and / or sulbactam.
Application during pregnancy and lactation
There is no evidence that the use of this drug is absolutely harmless to pregnant women and the fetus. Therefore, it is permissible to prescribe it when carrying a child only when the possible benefits of using the drug are higher than the possible harm.
During breastfeeding, the drug enters breast milk in some amount. As a result, lactation should be suspended during the treatment process.
Method of administration and dosage
Sulcef is administered as intramuscular or intravenous injections, twice a day, with a difference of 12 hours, in a single dose of 2-4 grams.
In severe cases, the dosage may be increased to 8 grams.
The duration of the course of treatment is determined by the attending physician, depending on the severity of the course of the disease.
In hepatic and renal failure, the dosage can be reduced to 2 grams per day (administered in a single dosage of 1 gram).
Overdose
In case of an overdose, an increase in side effects, the occurrence of seizures, can be expected.
In this case, gastric lavage, intake of sorbents, and symptomatic therapy are recommended.
Hemodialysis and symptom management are recommended.
Side effects
Side effects are usually mild and do not interfere with continuing treatment. Most often they appear as:

  • nausea, vomiting, pseudomembranous colitis, diarrhea (diarrhea);
  • skin rash, urticaria, Stevens-Johnson syndrome;
  • pain and / or phlebitis at the injection site, muscle twitching;
  • neutropenia, eosinophilia, thrombocytopenia, hematocrit, decreased hemoglobin.

There was also an increase in blood pressure, the occurrence of hematuria, vasculitis.
Storage conditions and periods
The shelf life of capsules is up to 2 years at a temperature of 30 ° C.