Tioctodar solution for injections 3% 10 ml. vial №1 0


Treatment of symptoms of peripheral (sensorimotor) diabetic polyneuropathy. Means that affect the digestive system and metabolic processes.



Composition and form of release
Main active ingredient: thioctic acid.
Auxiliary components are: trometamol, water for injection.
It is produced in the form of a concentrated solution for infusion. 1 ampoule with a volume of 10 ml contains 300 mg of thioctic acid.
Pharmacological properties
This pharmaceutical agent belongs to a group of drugs used in the treatment of certain types of diseases of the digestive system and metabolic processes in the body.
The drug owes its effect to the main therapeutic component – thioctic (lipoic) acid. The name “thioctacid” is also found. This medicinal substance from the group of vitamin-like components is an endogenous antioxidant.
Thioctic acid is an important cofactor and coenzyme involved in the oxidative decarboxylation of alpha-keto acids. Excess blood sugar (hyperglycemia) causes the accumulation of products of accelerated glycolysis, which, in turn, causes a decrease in blood flow and hypoxia, as well as ischemic changes. As a result, free radicals accumulate, damaging peripheral nerves.
Thioctic acid causes a decrease in blood glucose levels. The level of glycogen in the liver also increases. Insulin resistance increases.
Takes part in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism. It improves liver function, protects its resistance to the effects of free radicals and toxic substances.
It has hepatoprotective, hypolipidemic, hypocholesterolemic and hypoglycemic effects.
Used for the treatment of paresthesias (nervous sensitivity disorders) with complications of diabetes mellitus in the form of diabetic polyneuropathy.
The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.
The intake of alcoholic beverages is strictly prohibited.
Application during pregnancy and lactation
This drug is contraindicated in the treatment of pregnant women.
If it is necessary to administer the drug during breastfeeding, then lactation should be suspended for the duration of treatment.
Method of administration and dosage
If the paresthesias are intense, then treatment begins with the infusion of thioctic acid, then switch to oral administration.
The drug is diluted in a sodium chloride solution, and the volume of the drug in 300 mg of thioctic acid is administered for at least 30 minutes as an intravenous infusion. The bottle with the finished product is protected from sunlight with foil. It can be stored ready-made for up to 6 hours if stored in the refrigerator.
The drug is taken at 300-600 mg of thioctic acid per day, for 2-4 weeks.
When switching to oral administration in capsules or tablets, take 2 capsules of 300 mg each or 1 capsule of 600 mg of thioctic acid each. If food is taken earlier than 30 minutes later, it will complicate the absorption of the drug.
The total duration of the treatment course is 1-2 months.
During the entire course of treatment, blood sugar levels should be measured regularly, since taking thioctic acid can cause its decrease and hypoglycemic attacks.
It is possible to reduce the dose of insulin administered, depending on the blood sugar level.
At the beginning of the treatment course, a short-term increase in paresthesias in the form of “goose bumps” is possible.
Overdose can cause:

  • nausea, vomiting;
  • headache;
  • hypoglycemia;
  • shock, hemolysis.

When taken with alcohol – severe intoxication, up to death. It manifests itself in psychomotor agitation, convulsions, lactic acidosis.
Recommended gastric lavage, intake of enterosorbents, hospitalization, treatment of symptoms.
Side effects
In some cases, there may be some side effects in the form of:

  • changes and disturbances in taste;
  • nausea, vomiting, abdominal pain, diarrhea;
  • lowering blood sugar levels, hypoglycemic conditions (dizziness, increased sweating, headaches and visual impairments);
  • allergic reactions in the form of skin rash, allergic urticaria, itching, shortness of breath;
  • eczema, thrombophlebitis.

Storage conditions and periods
The shelf life is up to 3 years.
Storage temperature – no higher than 25 ° С.