Tivortin aspartate (L-arginine aspartate) oral solution 200 mg/ml. 100 ml. vial


Manufacturer: Ukraine

Used in the treatment of atherosclerosis of the vessels of the heart and brain, hypertension, atherosclerosis of peripheral vessels; chronic heart failure; hypercholesterolemia; chronic obstructive pulmonary disease, pulmonary hypertension; asthenic conditions.


Tivortin aspartate (L-arginine aspartate) oral solution 200 mg/ml. 100 ml. vial


active substance: L-arginine aspartate;

1 ml of solution contains L-arginine aspartate 200 mg;

Excipients: sorbitol (E 420), saccharin sodium (E 954), methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), Caramel flavoring, water for injections.

Dosage form

The solution is oral.

Main physical and chemical properties: slightly yellowish liquid with a caramel smell.

Pharmacotherapeutic group

Other cardiac drugs. Amino acids.
ATX code C01E.

Pharmacological properties

Tivortin aspartate oral solution has antihypoxic, cytoprotective, antioxidant, detoxifying, membrane-stabilizing effect. Plays an important role in the processes of neutralization of ammonia and stimulating its excretion from the body, enhances the detoxifying function of the liver. Has a hepatoprotective effect, has a positive effect on energy supply processes in hepatocytes.

As a donor of nitric oxide, Tivortin aspartate oral solution participates in the body’s energy supply processes, reduces the activation and adhesion of leukocytes and platelets to the vascular endothelium, preventing the formation and development of atherosclerotic plaques, is involved in fibrinogenolysis,

The drug has a moderate anabolic effect, stimulates the activity of the thymus gland, promotes insulin synthesis and regulates blood glucose during exercise, helps to correct acid-base balance.


The drug Tivortin aspartate oral solution is used and prescribed in complex treatment for such diseases:

  • cardiac ischemia;
  • atherosclerosis of the brain and heart vessels;
  • arterial hypertension;
  • atherosclerosis of peripheral vessels;
  • condition after suffering an acute myocardial infarction and acute cerebrovascular accident;
  • diabetic angiopathy;
  • myocardiopathy;
  • hypercholesterolemia;
  • interstitial pneumonia;
  • chronic heart failure;
  • chronic lung disease;
  • idiopathic pulmonary hypertension;
  • chronic postembolic pulmonary hypertension;
  • liver failure of various origins;
  • acute and chronic hepatitis;
  • hepatic encephalopathy;
  • hypoxic and asthenic conditions;
  • caused by hyperammonemia;
  • immunocorrection with a decrease in the function of the thymus gland.


The use of the drug Tivortin aspartat is contraindicated in patients with severe impairments in the functional activity of the kidneys, as well as in the presence of individual intolerance to the components of this drug.
Application during pregnancy and lactation
It is possible to use the drug Tivortin Aspartate for women, during pregnancy, as well as during lactation, as a last resort, only if the intended benefit to the mother significantly outweighs the potential risk to the fetus or child.

Method of administration and dosage

The drug Tivortin aspartate is intended for oral administration. The recommended dose is 5 ml (1 measuring spoon, which corresponds to 1 g of the drug) 3-8 times a day. It is necessary to take the solution directly during meals. The maximum permissible daily dose should not exceed 8 g. The duration of therapy is 1-2 weeks, if there is a need, the treatment can be repeated.


In case of an overdose of Tivortin Aspartate, hypersensitivity reactions, as well as hypoglycemic conditions, may occur. If these symptoms occur, it is necessary to rinse the stomach, take activated charcoal and stop using the drug.

Side effects

The use of the drug Tivortin Aspartate can cause mild discomfort in the intestines and stomach, nausea, but these side effects are temporary and gradually disappear. The manifestation of allergic reactions is also possible.