Tobradex (tobramycin, dexamethasone) eye drops 5 ml. vial


Manufacturer: Belgium

Inflammation of the eye in steroid-sensitive patients in whom corticosteroid use and superficial bacterial infection or risk of bacterial infection of the eye are indicated. These inflammatory processes may occur after surgery or may be caused by an infection, a foreign body in the eye, or an eye injury.


Tobradex (tobramycin, dexamethasone) eye drops 5 ml. vial


active ingredients: tobramycin, dexamethasone;

1 ml of suspension contains 3 mg of tobramycin and 1 mg of dexamethasone;

excipients: benzalkonium chloride, disodium edetate, sodium chloride, anhydrous sodium sulfate, tyloxapol, hydroxyethyl cellulose, sulfuric acid and / or sodium hydroxide, purified water.

Dosage form

Eye drops.

Basic physical and chemical properties: a suspension of white or almost white color.

Pharmacological group

Anti-inflammatory and antimicrobial agents in combination. Corticosteroids and antimicrobials in combination.
Code ATX S01C A01.

Pharmacological properties


The efficacy of corticosteroids for the treatment of anti-inflammatory conditions of the eye is well established. Corticosteroids achieve their anti-inflammatory action by inhibiting the adhesion of molecules to vascular endothelial cells, cyclooxygenase I or II, and the release of cytokines. As a result, the formation of inflammatory mediators decreases and the adhesion of circulating leukocytes to the vascular endothelium is inhibited, which prevents their penetration into the inflamed tissues of the eye. Dexamethasone has a pronounced anti-inflammatory effect with reduced mineralocorticoid activity compared to some other steroids and is one of the most potent anti-inflammatory drugs.


Tobramycin is a highly active, fast-acting bactericidal antibiotic of the aminoglycoside group, which counteracts both gram-positive and gram-negative microorganisms. Its mechanism of action is associated with the suppression of the complex of polypeptides and synthesis in the ribosomes of bacterial cells.


Tobradex eye drops is used in the treatment of patients who have inflammatory eye lesions of bacterial or non-bacterial etiology, such as blepharitis, keratitis and conjunctivitis without compromising the integrity of the ocular epithelium.
Tobradex is used for the prevention and treatment of infectious and inflammatory diseases of the eyes in patients who have undergone surgery, for example, removal of a foreign body or cataract.
The drug is prescribed to prevent the development of inflammatory and infectious diseases with eye injuries.


Tobradex eye drops is not prescribed to patients with hypersensitivity to its ingredients, as well as to those patients who have previously been diagnosed with keratitis or other eye diseases caused by mycobacterium tuberculosis, herpes virus, fungal infections and flora insensitive to tobramycin.
It makes no sense to use the drug with uncomplicated removal of a foreign body from the eye.
Tobradex in both dosage forms is not used in the treatment of children under 1 year of age.
It is recommended to responsibly treat the prescription of the drug to persons who have glaucoma or thinning of the cornea.
When treating Tobradex, you should avoid driving and driving dangerous machinery, as the drug can cause blurred and blurred vision.

Application during pregnancy and lactation

Lactation and pregnancy are considered absolute contraindications for the appointment of Tobradex.

Method of administration and dosage

Tobradex eye drops is used for instillation into the conjunctival sac. The patient should receive drops of 1 or 2 every 4 or 6 hours. At the beginning of treatment, for the first time 24 or 48 hours, the drug can be used in higher dosages: 1 or 2 drops every two hours.
When prescribing an ointment, a strip of the drug, no more than 1.5 cm long, is placed in the lower conjunctival sac from 3 to 4 times a day. To increase the effectiveness of treatment, it is recommended to combine the administration of drops and ointment.


With prolonged use of Tobradex in high doses, patients may experience irritation of the mucous membrane of the eyes, lacrimation, conjunctival hyperemia and swelling of the eyelids.
To eliminate discomfort, the patient is advised to rinse his eyes with warm running water and prescribe symptomatic treatment.

Side effects

The use of Tobradex may be accompanied by burning, dryness and itching of the mucous membranes of the eyes and eyelids, the sensation of a foreign body in the eye and allergic reactions. In rare cases, during treatment with the drug, patients may develop cataracts, mydriasis, glaucoma and photophobia.