Tomohexol is intended only for diagnostic studies. A radiopaque preparation for performing arthrography, angiography, arteriography, urography, phlebography and contrast enhancement in children and adults with computed tomography (CT), lumbar, chest and cervical myelography, CT cisternography, hysterosalpingography, sialography, endoscopic retrograde pancreatography (ERPG), endoscopic retrograde cholangiopancreatography (ERCP), herniography and gastrointestinal tract studies.
Composition and form of release
Active ingredient: yogexol 647 mg / ml (equivalent to 300 mg / ml iodine).
Tomohexol is available as a solution for injection / infusion.
It is an iodine-containing X-ray contrast agent. When administered intravascularly, it makes the blood flow opaque to X-rays, which provides radiographic visualization of the circulatory system.
Tomohexol is used:
- for angiography;
- for arthrography;
- for arteriography;
- for urography;
- for phlebography;
- for contrast enhancement in computed tomography;
- for cervical, thoracic, lumbar myelography;
- for CT cisternography;
- for hysterosalpingography;
- for sialography;
- for endoscopic retrograde pancreatography (ERPG);
- for endoscopic retrograde cholangiopancreatography (ERCP);
- for herniography;
- for studies of the gastrointestinal tract.
The drug Tomohexol is not used:
- with hypersensitivity to iodine-containing substances;
- in case of intolerance to excipients;
- with severe hyperthyroidism.
Apply with caution:
- in renal dysfunction;
- in diseases of the kidneys, liver;
- with homozygous sickle cell anemia;
- with multiple myeloma, other paraproteinemia;
- with anuria;
- in diabetes mellitus.
Use during pregnancy and breastfeeding
Studies do not indicate a direct or indirect negative impact on pregnancy, embryonic development, childbirth, postnatal development. However, sufficiently controlled studies have not been performed, so during pregnancy it is necessary to use the drug with extreme caution.
The ability of yoversol to be excreted in breast milk is unknown. But it is known that many injectable contrast agents are excreted unchanged in breast milk (approximately 1% of the administered dose). Although no adverse reactions have been identified, caution should be exercised when administering intravascularly to nursing patients. It is recommended to stop feeding for 24 hours.
Method of application and dose
Tomohexol is used according to the schemes in the instructions.
Apply the lowest dose that provides adequate visualization.
Overdose can be potentially life-threatening, manifested by cardiovascular and respiratory disorders.
Treatment is symptomatic, hemodialysis is indicated.
- Immune disorders: manifestations of allergies, including anaphylactoid reactions, anaphylactic shock.
- Mental disorders: agitation, confusion, anxiety.
- Neurological disorders: fainting, vertigo, tremor, headache, delirium, paresthesias, taste disturbances, loss of consciousness, speech impairment, paralysis, drowsiness, aphasia, stupor, dysphasia, hypoaesthesia, dyskinesia, convulsions, amnesia.
- Ophthalmic disorders: blurred vision, allergic conjunctivitis, eye irritation, tearing, redness, conjunctival edema, transient blindness.
- Otolaryngological disorders: ringing in the ears.
- Cardiovascular disorders: tachycardia, heart block, ECG changes, bradycardia, arrhythmia, angina, atrial fibrillation, cardiac arrest, coronary artery spasm, ventricular fibrillation, cyanosis, palpitations, extrasystole, hypertension / hypotension, hypotension, hypotension, hypotension phlebitis, vasodilation, vasospasm, shock, thrombosis, hemodynamic collapse.
- Respiratory disorders: laryngospasm, edema, airway obstruction, nasal congestion, stridor, shortness of breath, sneezing, cough, sore throat, pulmonary edema, hypoxia, pharyngitis, respiratory arrest, bronchospasm, apnea, asthma, dysphonia.
- Gastrointestinal disorders: dry mouth, nausea, sialadenitis, swelling of the tongue, abdominal pain, dysphagia, diarrhea, hypersalivation.
- Dermatological disorders: urticaria, rash, erythema, pruritus, Quincke’s edema, pallor, hyperhidrosis, toxic epidermal necrolysis.
- Musculoskeletal disorders: muscle cramps.
- Urinary disorders: involuntary urination, renal failure, decreased creatinine clearance, incontinence, hematuria, increased urea, dysuria, anuria, oliguria.
- General: fever, edema, pharyngeal edema, chills, tremor, changes in the injection site (pain, hemorrhage, erythema, necrosis), asthenic conditions, malaise, chest pain, hyperthermia.
Conditions and terms of storage
Store Tomohexol at a temperature up to +25 ° C no more than three years.