Antiepileptic drugs. As monotherapy for the treatment of adults and children from the age of 6 with partial onset seizures with or without secondary generalized seizures and initially generalized tonic-clonic seizures. As adjunctive therapy for the treatment of adults and children 2 years of age with partial onset seizures with or without secondary generalized seizures or initially generalized tonic-clonic seizures and treatment of seizures associated with Lennox-Gasto syndrome. For the prevention of migraine attacks in adults, after careful evaluation of alternative treatment options. Topiramate is not recommended for the treatment of acute conditions.
Composition and form of release
The active ingredient is topiramate. Also contains excipients. Produced in tablet form.
An antiepileptic drug, belongs to the group of sulfamate-substituted monosachyrides. It is prescribed for the treatment of epilepsy, the prevention of migraine attacks, partial or generalized tonic-clonic seizures, and seizures against the background of Lennox-Gastaut syndrome.
The ability to stop seizures of Topamax is caused by the ability of its main active ingredient, topiramate, to block sodium channels in neurons, and suppress the potentials of repeated actions during depolarization of neuronal cell membranes, and for a long time. The effect of Topamax is dose-dependent.
Not prescribed for children under 2 children, as well as for allergies to topiramate or one of the excipients that make up Topamax.
Care should be taken when treating patients who suffer from renal or hepatic insufficiency, nephrourolithiasis, hypercalciuria.
Application during pregnancy and lactation
There is no data that would indicate the complete safety of the use of Topamax for women during the period of bearing a child, because clinical studies of the drug on pregnant women are not carried out.
Method of administration and dosage
Topamax is taken regardless of food. Treatment begins with minimal doses (25 mg), after 1-2 weeks it can be doubled. The optimal dosage is 0.1-0.2 grams per day, the maximum is 0.5 mg.
When used in combination therapy, the starting dose can be up to 50 mg. The daily dose for joint therapy is from 200 to 400 mg.
In order to prevent migraine attacks, Topamax is taken at 100 mg per day.
When the drug is canceled, the dosage is reduced in stages.
A more accurate dosage is determined by the attending physician.
Symptoms of an overdose of Topamax are convulsions, a state of arousal, impaired thinking, movements, vision, speech, and a drop in pressure. With more severe intoxication, lethargy, diplopia, stupor, metabolic acidosis are possible.
Taking Topamax can be accompanied primarily by a reaction from the central nervous system, in particular, nervousness, seizures, psychomotor disorders, ataxia, fatigue, diplopia, nystagmus, depression, drowsiness, aggression. Children may experience hallucinations.
The gastrointestinal tract reacts with nausea, anorexia, hepatitis, liver failure. Possible side effects from the organs of vision, including secondary glaucoma may develop).
Storage conditions and periods
It is able to retain its medicinal properties for up to 3 years, subject to storage conditions – out of direct sunlight and an ambient temperature not higher than + 25 ° C.