Atherosclerotic encephalopathy; ischemic cerebral stroke; dyscirculatory encephalopathy; disorders of peripheral circulation, caused by atherosclerosis, diabetes (including diabetic angiopathy), inflammation; trophic disorders in tissues associated with vein lesions or microcirculation disorders (post-thrombophlebitis syndrome, trophic ulcers, gangrene, frostbite); obliterating endarteritis; angioneuropathy (Raynaud’s disease); impaired circulation of the eye (acute, subacute, chronic circulatory insufficiency in the retina and vascular sheath of the eye); impaired function of the inner ear of the vascular genesis, accompanied by hearing loss.
Composition and form of release
Trental is produced in tablets and concentrate for preparation of solution for infusions. The active substance is pentoxifylline.
Trental is used in the treatment of peripheral circulatory disorders of atherosclerotic genesis, trophic disorders, frostbite and post-thrombotic syndrome.
The drug is used in the treatment of cerebral circulatory disorders, as well as ischemic and post-stroke conditions, accompanied by impaired concentration, memory loss and dizziness.
Trental is indicated for circulatory disorders in the choroid and retina. It is used in the treatment of otosclerosis, degenerative changes caused by vascular pathology in the inner ear and hearing loss.
Trental cannot be used in the treatment of patients with a tendency to bleeding, pentoxifylline intolerance, pregnant and lactating. In addition, Trental is not prescribed to patients who have recently suffered a hemorrhagic stroke or bleeding into the retina.
Care should be taken to prescribe the drug to patients who suffer from severe forms of atherosclerosis of the coronary and cerebral vessels, ischemic heart disease, arrhythmia and have a predisposition to a sharp increase in pressure. Also, Trental is used with caution if the patient has a history of diseases of the digestive tract or heart failure.
Application during pregnancy and lactation
Trental is contraindicated in pregnant women. When prescribing the drug to women at the lactation stage, the patient must first stop breastfeeding.
Method of administration and dosage
Trental in solution for infusions is intended for jet or drip injection. Before use, the concentrate is dissolved in an isotonic glucose solution. Pentoxifylline is prescribed 100 or 600 mg 1 or 2 times per knock. In patients with severe circulatory disorders, the duration of the infusion can be up to 24 hours. When administered intravenously, the daily dose of the drug should not exceed 1200 mg. During intravenous administration of the drug, the patient should be in a horizontal position.
When prescribing Trental in oral form, the dose of the drug and the duration of treatment are selected by the doctor individually. If there are no other recommendations, then the drug is taken 2 or 4 tablets from 2 to 3 times per knock. The tablets should be swallowed whole after meals. The daily dose of the drug should not exceed 1200 mg.
In case of an overdose of Trental, the patient develops vomiting, nausea, dizziness, increased heart rate, fever, agitation, convulsions, loss of consciousness and areflexia.
To stabilize the patient’s condition, gastric lavage is carried out, an abundant drink is prescribed, enterosorbents are taken and symptomatic treatment.
Sometimes, when taking Trental, it is possible to develop dyspeptic disorders, abdominal pain, gastrointestinal bleeding, heart rhythm disturbances, headaches, sleep disturbances, increased irritability, causeless anxiety, and allergic reactions.
Storage conditions and periods
It is recommended to store Trental in a dry, dark place out of the reach of children. Duration of storage of the drug is 4 years.