Stomach ache; cramping a feeling of fullness; flatulence; constipation or diarrhea; irritable bowel syndrome.
active substance: trimebutine maleate;
1 tablet contains Trimebutin maleate 200 mg
excipients: microcrystalline cellulose, lactose, tartaric acid, corn starch, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, hypromellose, diethyl phthalate, titanium dioxide (E 171), talc.
Basic physical and chemical properties
round biconvex tablets of white color, film-coated, smooth on both sides.
Trimebutin is a synthetic agonist of peripheral opioid receptors m, d and k. The mechanism of action consists in direct action on the smooth muscles of the digestive tract and in the regulation of motor disorders without affecting the central nervous system. Unlike other opioids, trimebutin is not characterized by selectivity for one of the three types of receptors, due to which it can both enhance and suppress peristalsis. The process of normalization of motor skills begins 30 minutes after application of the drug.
Irritable bowel syndrome; functional disorders of the digestive tract, accompanied by abdominal pain, cramps, a feeling of fullness, flatulence, constipation or diarrhea.
Hypersensitivity to trimebutin or other components of the drug.
The drug Trimspa 200 can cause drowsiness, therefore, the drug should be used with caution in patients with depression of the central nervous system.
Trimspa 200 can increase the sedative effect of drugs that depress the central nervous system and / or ethanol.
The drug contains lactose, therefore, patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.
Use during pregnancy or lactation
Since there are no data on the use of the drug during pregnancy and lactation, it is contraindicated to prescribe to women during this period. Breastfeeding should be discontinued during treatment.
The ability to influence the reaction rate when driving vehicles or other mechanisms
In case of dizziness or drowsiness, you should refrain from driving or operating machinery.
Method of administration and dosage
Take the tablets by mouth with a glass of boiled water.
For adults, a single dose is 200 mg (1 tablet), the daily dose is 600 mg (3 tablets).
At the beginning of the treatment of irritable bowel syndrome, the maximum daily dose, if necessary, can be 600 mg (3 tablets), divided into 3 doses (i.e., 1 tablet 3 times a day).
The duration of the course of therapy is determined by the doctor individually, depending on the severity of the disease. Usually, the course of treatment is 2-6 weeks, depending on the severity of the disease.
The experience of using the drug in children is limited, so it should not be prescribed to this category of patients.
There are no data on cases of trimebutin overdose. Possible increased manifestations of adverse reactions.
- From the digestive tract: dry mouth, taste disturbance, diarrhea, dyspepsia, stomach pain, nausea, constipation.
- From the nervous system: drowsiness, fatigue, dizziness, anxiety, headache, feeling cold / warm, hearing impairment.
- From the immune system: allergic reactions, including skin rashes.
- Reproductive disorders: menstrual irregularities, painful breast enlargement.
- From the kidneys and urinary tract: urinary retention.
Store at a temperature not exceeding 25 ° C in its original packaging.
Keep out of the reach of children.