Trittico prolonged release tablets 75 mg. №30


Depressive disorders with / without anxiety. Psychoanalytics. Antidepressants. Other antidepressants.



active substance: trazodone hydrochloride
1 tablet contains trazodone hydrochloride 150 mg;
excipients: hypromellose, colloidal anhydrous silica, sodium stearyl fumarate, modified pregelatinized starch (E 1442);
shell composition:coating mixture “Opadry® II, Yellow 85F92421” (polyvinyl alcohol, talc, macrogol, titanium dioxide (E 171), iron oxide yellow (E 172), iron oxide red (E 172)).
Dosage form
Prolonged-release film-coated tablets.
Basic physical and chemical properties: yellow-beige oblong film-coated tablets with a central fracture line on both sides.
Pharmacological properties
The drug combines antidepressant (thymoleptic) with anxiolytic (tranquilizing) action. Selectively inhibits neuronal reuptake of serotonin, blocks α-adrenergic receptors.
It is quickly and completely absorbed in the digestive tract; simultaneous food intake slows down the absorption of trazodone. Cmax in blood plasma is reached approximately 1 hour after administration. Penetrates through histohematogenous barriers, including the BBB. Penetrates into tissues and secretions (bile, saliva, breast milk, etc.). In the liver, it undergoes biotransformation. Elimination is biphasic with T1 / 2 in the first phase 36 hours, and 59 hours in the second. Cumulation in the body is possible. It is excreted mainly in the urine unchanged and in the form of metabolites.
depressions, bulimia, kleptomania, prevention of migraine, anxiety, phobias (including agoraphobia), acute alcohol withdrawal syndrome, benzodiazepine dependence.
inside, on an empty stomach. As an antidepressant – 50 mg 3 times a day, then, depending on the severity of depression, the dose is gradually increased (50 mg every 3-4 days) to 300–500 mg / day (maximum daily dose is 600 mg); the maintenance dose is set individually. As an anxiolytic – 25 mg 3 times a day.
Prototype indications
hypersensitivity to trazodone, history of priapism, early post-infarction period, heart rhythm disturbances, severe liver and kidney dysfunction, pregnancy and lactation.
Side effects
visual disturbances, eye irritation, nasal congestion, constipation, diarrhea, a feeling of dryness and bitterness in the mouth, nausea, vomiting, dizziness, drowsiness, increased fatigue, headache, myalgia, discoordination, paresthesias, disorientation, impaired consciousness, tremor, heart rhythm disturbances and conduction, arterial hypotension, orthostatic reactions, leukopenia, neutropenia, priapism followed by impotence, angioedema, skin-allergic reactions.
symptoms: nausea, drowsiness, priapism, respiratory arrest, epileptiform seizures, ECG changes.
Treatment: gastric lavage and forced diuresis to accelerate elimination, maintenance of vital functions.
Expiration date
4 years.
Storage conditions
This medicine does not require any special storage conditions. Half of the tablet can be stored for 24 hours in the original package to protect from light