Trizipin (meldonium) solution for injections 100 mg/ml. 5 ml. vials №10


Manufacturer: Ukraine

In complex therapy in the following cases: heart and vascular diseases: stable angina, chronic heart failure (NYHA I-i functional class), cardiomyopathy, functional disorders of the heart and vascular system; acute and chronic ischemic disorders of the cerebral circulation; reduced working capacity, physical and psycho-emotional stress; during recovery from cerebrovascular disorders, head trauma and encephalitis.


Trizipin (meldonium) solution for injections 100 mg/ml. 5 ml. vials №10


active substance: meldonium;

1 ampoule of 5 ml contains 3- (2,2,2-trimethylhydrazinium) propionate dihydrate 0.5 g;

Excipient: water for injections.

Dosage form

Solution for injection.

Basic physical and chemical properties: transparent colorless liquid.

Pharmacotherapeutic group

Other cardiac drugs. Meldonium.
ATX code C01E B22.

Pharmacological properties

It is a remedy that improves metabolic processes in the heart muscle. In conditions of ischemia (insufficient blood supply), it restores the cellular balance between oxygen consumption and its delivery, prevents disruption of ATP transport, activates glycolysis without additional oxygen consumption. It helps to increase performance, reduce the severity of signs of physical and mental overstrain, activate immunity. Has a cardioprotective effect. In case of acute ischemic myocardial injury, it reduces the area of ​​necrosis and shortens the rehabilitation period.


Trizipin solution is used:

  • with diseases of the heart, vascular system (chronic insufficiency, stable exertional angina, cardiomyopathy, functional disorders);
  • with acute / chronic disorders of cerebral circulation;
  • with reduced performance, psychoemotional or physical overstrain;
  • during the recovery period after head injuries, cerebrovascular disorders, encephalitis.


Trizipin solution is contraindicated:

  • with intolerance to the components of the drug;
  • with increased intraocular pressure;
  • with severe dysfunction of the liver, kidneys.

Application during pregnancy and lactation


Method of administration and dosage
Trizipin solution is administered intravenously, preferably in the morning.

The dose is 500-1000 mg (5-10 ml) per day, the dose is administered at once or divided into 2 doses. The duration of treatment is usually 10-14 days, after which treatment is continued with oral dosage form.

The duration of treatment is 4-6 weeks. The course of treatment can be repeated 2-3 times a year.


The drug is low toxic.
Possible symptoms: decreased blood pressure, tachycardia, dizziness, weakness.
Treatment is symptomatic. Monitoring of kidney and liver function is necessary.

Side effects:

  • Urinary disorders: pollakiuria.
  • Immune disorders: allergic dermatitis, urticaria, angioedema, anaphylactic reactions.
  • Mental disorders: sleep disturbances, fear, agitation, obsessive thoughts.
  • Neurological disorders: paresthesia, cephalalgia, tremor, vertigo, hypesthesia, tinnitus, gait disturbance, loss of consciousness.
  • Cardiovascular disorders: palpitations, cardiac arrhythmias, tachycardia, discomfort in the region of the heart, atrial fibrillation, instability of blood pressure, hyperemia, pallor of the skin, hypertensive crisis.
  • Respiratory disorders: pharyngitis, cough, apnea, dyspnea.
  • Gastrointestinal disorders: dyspepsia, loss of appetite, dysgeusia (metallic taste in the mouth), nausea, diarrhea, flatulence, hypersalivation, dry mouth.
  • Dermatological disorders: macular, papular eruptions, itching.
  • Musculoskeletal disorders: back pain, myasthenia gravis, muscle spasms.
  • General: weakness, asthenia, chills, swelling of the legs, face, cold sweat, feeling hot or cold.
  • Laboratory changes: increased levels of C-reactive protein, dyslipidemia, abnormalities in the electrocardiogram, eosinophilia, tachycardia.