Schizophrenia and other psychoses with psychomotor anxiety, agitation and anxiety disorder.
Truxal (chlorprothixene) coated tablets 25 mg. №100 vial
active substance: chlorprothixene;
1 tablet contains 25 mg or 50 mg of chlorprothixene hydrochloride;
excipients: corn starch; lactose monohydrate; copovidone; glycerin (85%); microcrystalline cellulose; croscarmellose sodium; talc; magnesium stearate; OPADRY OY-S-9478 covering brown.
Main physical and chemical properties: 25 mg tablets – round, biconvex film-coated tablets, dark brown; 50 mg tablets – oval, biconvex film-coated tablets, dark brown.
Psycholeptics. Antipsychotics. Thioxanthene derivatives. Chlorprothixene.
ATX code N05A F03.
Chlorprothixene is a neuroleptic from the thioxanthene group.
The antipsychotic effect of neuroleptics is associated with blockade of dopamine receptors, but also with the possible involvement of 5-HT (5-hydroxytryptamine) receptors in this process.
Chlorprothixene has a high affinity for 5-HT2 receptors and α1-adrenoceptors and is similar in this respect to high-dose phenothiazines, levomepromazine, chlorpromazine, thioridazine and the atypical neuroleptic clozapine. It has a high histamine (H1) affinity, which is equal to the affinity of diphenhydramine. Chlorprothixene shows high affinity for cholinergic muscarinic receptors. The receptor binding profile is quite similar to that of clozapine, although chlorprothixene has almost 10-fold greater affinity for dopamine receptors.
Chlorprothixene is a sedative neuroleptic with a wide range of indications.
Chlorprothixene reduces or eliminates anxiety, obsessions, psychomotor agitation, anxiety, nervousness and insomnia, as well as hallucinations, mania and other psychotic symptoms. In low doses it has an antidepressant effect, which makes it acceptable for the treatment of mental disorders accompanied by anxiety-anxiety-depression syndrome; psychosomatic disorders.
Chlorprothixene does not cause addiction, dependence and tolerance. Thus, chlorprothixene is effective in the treatment of both psychotic states and a wide range of other mental disorders. In addition, chlorprothixene enhances the action of analgesics, has its own analgesic effect, antipruritic and antiemetic properties.
Truxal coated tablets is used to treat psychosis (without a symptom of depression of consciousness), including mania and schizophrenia, as well as for the treatment of withdrawal symptoms, age-related hyperactivity, neuroses, insomnia, depression, pain syndrome, psychosomatic disorders, behavioral disorders in pediatrics.
The active ingredients of the drug are able to block dopamine receptors, due to which the mechanism of sedation is triggered, antidepressant and analgesic effects are manifested. Truxal coated tablets also has adrenergic blocking, antihistamine activity, lowers blood pressure.
It is contraindicated to use in case of poisoning with barbiturates, opiates, alcohol, allergies to the substances that make up it. It is not prescribed for parkinsonism, diabetes mellitus, atherosclerosis, tendency to collapse, epilepsy, in childhood.
This pharmaceutical should not be used if the patient suffers from insufficiency of the heart, kidneys, liver, and finally, with prostatitis.
Application during pregnancy and lactation
Method of administration and dosage
The dosage is prescribed and adjusted by the doctor after an individual assessment of the patient’s condition. Treatment starts with a small dosage, then gradually increases until it is optimally effective.
Schizophrenia, mental states, mania: the starting dose is 50-100 mg per day, with a gradual increase to the optimal 300 mg. The maximum daily dose is 1200. The maintenance dose is 100-200 mg. The application is divided into 2-3 doses during the day, with a large dose in the evening.
Withdrawal symptoms: 500 mg per day, treatment lasts for one week. After reaching the therapeutic effect, the dose is gradually reduced. The maintenance dose is 100 mg, which are taken in parts (in the morning and afternoon – 25 mg each, in the evening – 50 milligrams). After some time, the dose can be reduced.
Depression, neuroses, psychosomatic disorders: from 25 to 100-150 mg per day. Reception is also divided into 3 parts.
Sleep disturbances: 25 mg at night. Epilepsy, oligophrenia: 100-125 mg. Chronic pain, a combination with analgesics is possible: the initial dose is 75-100 mg, the dosage can be gradually increased to 200-300 mg.
Overdose can cause drowsiness, coma, shock, hypothermia, hyperthermia, kidney damage. Symptomatic therapy is prescribed.
Taking this drug can cause side effects in the form of drowsiness, jaundice, gynecomastia in men, hyperhidrosis, weakening of potency, libido, dysmenorrhea, drop in blood pressure, tachycardia, seizures. In rare cases, excessive weight gain, constipation, anemia, galactorrhea, benign leukopenia, and dysmenorrhea have occurred.