Unipack is for diagnostic use only. X-ray contrast preparation for use by children and adults for cardio angiography, arteriography, urography, phlebography and contrast enhancement in computed tomography (CT); lumbar, thoracic and cervical myelography, CT-cisternography after subarachnoid administration; arthrography, endoscopic retrograde pancreatography (ERPG), endoscopic retrograde cholangiopancreatography (ERHPG), hernia, hysterosalpingography, sialography and gastrointestinal studies.
Composition and form of release
Active ingredient: iohexol 518 mg / ml (equivalent to 240 mg / ml of iodine), 647 mg / ml (equivalent to 300 mg / ml of iodine), 755 mg / ml (equivalent to 350 mg / ml of iodine).
Unipack is produced in the form of a solution for injection / infusion.
It is an iodine-containing radiopaque substance. When injected intravascularly, it makes the blood flow opaque to X-rays, which provides radiographic imaging of the circulatory system of organs.
Unipack is used:
- for angiography;
- for arthrography;
- for arteriography;
- for urography;
- for phlebography;
- for contrast enhancement in computed tomography;
- for cervical, thoracic, lumbar myelography;
- for CT cisternography;
- for hysterosalpingography;
- for sialography;
- for endoscopic retrograde pancreatography (ERPG);
- for endoscopic retrograde cholangiopancreatography (ERCP);
- for herniography;
- for studies of the gastrointestinal tract.
The drug Unipack is not used:
- with increased sensitivity to iodine-containing substances;
- with intolerance to excipients;
- with severe hyperthyroidism.
Used with caution:
- in case of impaired renal function;
- with diseases of the kidneys, liver;
- with homozygous sickle cell anemia;
- with multiple myeloma, other paraproteinemia;
- with anuria;
- with diabetes mellitus.
Application during pregnancy and lactation
Studies do not indicate a direct or indirect negative impact on the course of pregnancy, embryo development, childbirth, postnatal development. However, sufficiently controlled studies have not been conducted, therefore, during pregnancy, it is necessary to use the drug with extreme caution.
The ability of Joversol to be excreted in breast milk is unknown. But it is known that many injectable contrast agents are excreted unchanged in breast milk (approximately 1% of the administered dose). Although no adverse reactions have been identified, caution should be exercised with intravascular administration to nursing patients. It is recommended to stop feeding for 24 hours.
Method of administration and dosage
Unipack is used according to the diagrams in the instructions.
Apply the lowest dose that provides adequate visualization.
Overdose can be potentially life-threatening, manifested by cardiovascular and respiratory disorders.
Treatment is symptomatic, hemodialysis is indicated.
Immune disorders: manifestations of allergies, incl. anaphylactoid reactions, anaphylactic shock.
Mental disorders: agitation, confusion, anxiety.
Neurological disorders: fainting, vertigo, tremor, headache, delirium, paresthesia, taste disturbances, loss of consciousness, speech impairment, paralysis, drowsiness, aphasia, stupor, dysphasia, hypesthesia, dyskinesia, convulsions, amnesia.
Ophthalmic disorders: blurred vision, allergic conjunctivitis, eye irritation, lacrimation, redness, conjunctival edema, transient blindness.
Otolaryngological disorders: ringing in the ears.
Cardiovascular disorders: tachycardia, heart block, ECG changes, bradycardia, arrhythmia, angina pectoris, atrial fibrillation, cardiac arrest, coronary artery spasm, ventricular fibrillation, cyanosis, palpitations, extrasystole, arterial hypotension, circulatory hypertension, hypotension / hypertension, hypotension phlebitis, vasodilation, vasospasm, shock, thrombosis, hemodynamic collapse.
Respiratory disorders: laryngospasm, edema, airway obstruction, nasal congestion, stridor, shortness of breath, sneezing, cough, sore throat, pulmonary edema, hypoxia, pharyngitis, respiratory arrest, bronchospasm, apnea, asthma, dysphonia.
Gastrointestinal disorders: dry mouth, nausea, sialadenitis, tongue edema, abdominal pain, dysphagia, diarrhea, hypersalivation.
Dermatological disorders: urticaria, rash, erythema, pruritus, Quincke’s edema, pallor, hyperhidrosis, toxic epidermal necrolysis.
Musculoskeletal disorders: muscle cramps.
Urinary disorders: involuntary urination, renal failure, decreased creatinine clearance, incontinence, hematuria, increased urea levels, dysuria, anuria, oliguria.
General: fever, facial edema, pharyngeal edema, chills, tremors, changes at the injection site (pain, hemorrhage, erythema, necrosis), asthenic conditions, feeling unwell, chest pain, hyperthermia.
Storage conditions and periods
Store Unipack at temperatures up to +25 ° С for no more than three years.