Zanidip (lercanidipine hydrochloride) coated tablets 20 mg. №56


Essential hypertension of mild or moderate severity. Selective calcium antagonists with a predominant effect on blood vessels. Dihydropyridine derivatives.



Zanidip composition and form of release
The drug Zanidip is available in the form of tablets, round and biconvex, have a notch on one side, covered with a film coating. Red tablets.
The main component of the drug Zanidip is lercanidipine 20 mg, auxiliary components: microcrystalline cellulose, lactose, sodium starch, magnesium stearate, povidone, opadri, titanium dioxide, hypromellose, talc, iron dye oxide yellow and red, 6 macro. 56 tablets in blister packs.

Pharmacological properties
Zanidip is an effective blocker of slow calcium channels. This agent selectively blocks the influx of calcium ions into the heart cells, as well as into smooth muscle cells and the vascular wall. Its prolonged antihypertensive effect is due to a direct relaxing effect on vascular smooth muscle, resulting in a decrease in total vascular peripheral resistance.

Indications for use
Zanidip is used to treat essential hypertension of mild or moderate severity.

Zanidip has contraindications to use: hypersensitivity reactions to the components that are part of this tool, obstruction of the vessels leaving the left ventricle, unstable angina, congestive heart failure. Also, the drug should not be taken in patients with liver and kidney problems, if creatinine clearance <30 ml / min, patients who have suffered a myocardial infarction within 1 month, women of childbearing potential who are planning a pregnancy and do not use effective contraception, use concomitantly with cyclosporine , CYP ZA4 inhibitors, grapefruit juice, pediatric patients.

Use during pregnancy and breastfeeding
The use of Zanidip for pregnant women and during breastfeeding is contraindicated.
Method of application and dose
The use of Zanidip for the treatment of essential hypertension in mild or moderate form, start with a dose of 10 mg once a day, preferably in the morning, about 15 minutes before meals. If necessary on the advice of a doctor, the dose is increased to 20 mg.
The dose of the drug should be increased gradually, as the maximum positive effect occurs after two weeks of treatment.
It is also possible to use the drug Zanidit in combination therapy with diuretics, b-blockers, ACE inhibitors.
The tablets should be taken whole, without chewing, with plenty of water.

Signs of Zanidip overdose are: excessive peripheral vasodilation, hypotension, reflex tachycardia, myocardial infarction and angina. In case of these symptoms, it is necessary to use cardiovascular drugs, intravenous atropine, as well as during the day to monitor the patient’s hemodynamics.

Side effects
The use of the drug Zanidip can cause quite a number of side effects, the most common of which are headache, peripheral edema, dizziness, tachycardia, palpitations and hot flashes. In rare cases, side effects may include drowsiness, angina, epigastric pain, diarrhea, dyspepsia, nausea and vomiting, rash, myalgia, polyuria, asthenia, and fatigue.
In exceptional cases, other side effects are also possible with the use of the drug Zanidip: hypersensitivity, fainting, hypertrophic gingivitis, hypotension, increased levels of hepatic transaminases in the blood, increased frequency of urination, angina, chest pain, myocardial infarction.

Conditions and terms of storage
The drug Zanidip is not difficult to store: the optimal temperature for storage is not higher than + 30 ° C, the original packaging, as well as that the drug does not fall into the hands of children. The maximum shelf life, which the manufacturer indicates on the packaging of this drug, is 3 years from the date of manufacture.